General Structure Information
| PDB ID | 2i6l |
| HGNC Gene Label(s) | MAPK6 |
| Structure Name | crystal structure of human mitogen activated protein kinase 6 (mapk6) |
| Resolution | 2.25Å |
| Reference | AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,P.SAVITSKY,AUTH 2 O.FEDOROV,G.BERRIDGE,S.DAS,J.ELKINS,AUTH 3 M.SOUNDARARAJAN,X.W.YANG,D.DOYLE,E.PAPAGRIGORIOU,AUTH 4 A.C.W.PIKE,G.BUNKONCZI,E.UGOCHUKWU,J.DEBRECZENI,AUTH 5 F.VON DELFT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 6 S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN MITOGEN ACTIVATEDTITL 2 PROTEIN KINASE 6REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 269 |
| Number Of SNVs | 41 |
| Number Of Permutations | 6800 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.313 |
| p-value | 0.849 |
COSMIC
| Number Of Residues | 269 |
| Number Of SNVs | 5 |
| Number Of Permutations | 581 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.2 |
| p-value | 0.949 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.099 |
| p-value | 0.678 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
