General Structure Information
| PDB ID | 3ucr |
| HGNC Gene Label(s) | TIGIT |
| Structure Name | crystal structure of the immunoreceptor tigit igv domain |
| Resolution | 2.63Å |
| Reference | AUTH K.F.STENGEL,K.HARDEN-BOWLES,X.YU,L.ROUGE,J.YIN,AUTH 2 L.COMPS-AGRAR,C.WIESMANN,J.F.BAZAN,D.L.EATON,J.L.GROGANTITL STRUCTURE OF TIGIT IMMUNORECEPTOR BOUND TO POLIOVIRUSTITL 2 RECEPTOR REVEALS A CELL-CELL ADHESION AND SIGNALINGTITL 3 MECHANISM THAT REQUIRES CIS-TRANS RECEPTOR CLUSTERING.REF PROC.NATL.ACAD.SCI.USA V. 109 5399 2012REFN ISSN 0027-8424PMID 22421438DOI 10.1073/PNAS.1120606109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 106 |
| Number Of SNVs | 27 |
| Number Of Permutations | 9297 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.171 |
| p-value | 0.864 |
COSMIC
| Number Of Residues | 106 |
| Number Of SNVs | 4 |
| Number Of Permutations | 356 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.167 |
| p-value | 0.568 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.365 |
| p-value | 0.228 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
