General Structure Information
| PDB ID | 3e9l |
| HGNC Gene Label(s) | PRPF8 |
| Structure Name | crystal structure of human prp8, residues 1755-2016 |
| Resolution | 1.95Å |
| Reference | AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 257 |
| Number Of SNVs | 9 |
| Number Of Permutations | 3722 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.139 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 257 |
| Number Of SNVs | 6 |
| Number Of Permutations | 948 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.267 |
| p-value | 0.439 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 9 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.5 |
| p-value | 0.076 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
