General Structure Information
| PDB ID | 3she |
| HGNC Gene Label(s) | MAPKAPK3 |
| Structure Name | novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series |
| Resolution | 2.25Å |
| Reference | AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 2012REFN ISSN 0960-894XPMID 22119462DOI 10.1016/J.BMCL.2011.10.071 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 270 |
| Number Of SNVs | 51 |
| Number Of Permutations | 25890 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.256 |
| p-value | 0.094 |
COSMIC
| Number Of Residues | 270 |
| Number Of SNVs | 4 |
| Number Of Permutations | 43 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.167 |
| p-value | 0.472 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.256 |
| p-value | 0.321 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
