General Structure Information
| PDB ID | 4mq2 |
| HGNC Gene Label(s) | DYRK1A |
| Structure Name | the crystal structure of dyrk1a with a bound pyrido[2,3-d]pyrimidine inhibitor |
| Resolution | 2.8Å |
| Reference | AUTH K.ANDERSON,Y.CHEN,Z.CHEN,R.DOMINIQUE,K.GLENN,Y.HE,C.JANSON,AUTH 2 K.C.LUK,C.LUKACS,A.POLONSKAIA,Q.QIAO,A.RAILKAR,P.ROSSMAN,AUTH 3 H.SUN,Q.XIANG,M.VILENCHIK,P.WOVKULICH,X.ZHANGTITL PYRIDO[2,3-D]PYRIMIDINES: DISCOVERY AND PRELIMINARY SAR OF ATITL 2 NOVEL SERIES OF DYRK1B AND DYRK1A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 6610 2013REFN ISSN 0960-894XPMID 24239188DOI 10.1016/J.BMCL.2013.10.055 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 33 |
| Number Of Permutations | 18455 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.07 |
| p-value | 0.899 |
ClinVar
| Number Of Residues | 329 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2177 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.667 |
| p-value | 0.055 |
COSMIC
| Number Of Residues | 329 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.871 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.661 |
| p-value | 0.048 |
Cosmic vs. ExAC
