General Structure Information
| PDB ID | 2me6 |
| HGNC Gene Label(s) | GBX1 |
| Structure Name | nmr structure of the homeodomain transcription factor gbx1 from homo sapiens in complex with the dna sequence cgactaattagtcg |
| Resolution | -1.0Å |
| Reference | AUTH A.PROUDFOOT,K.WUTHRICH,P.SERRANO,M.GERALTTITL NMR STRUCTURE OF THE HOMEODOMAIN TRANSCRIPTION FACTOR GBX1TITL 2 FROM HOMO SAPIENS IN COMPLEX WITH THE DNA SEQUENCETITL 3 CGACTAATTAGTCGREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 70 |
| Number Of SNVs | 14 |
| Number Of Permutations | 7857 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.099 |
| p-value | 0.597 |
COSMIC
| Number Of Residues | 70 |
| Number Of SNVs | 4 |
| Number Of Permutations | 292 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.167 |
| p-value | 0.307 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.625 |
| p-value | 0.11 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
