General Structure Information
| PDB ID | 2a8b |
| HGNC Gene Label(s) | PTPRR |
| Structure Name | crystal structure of the catalytic domain of human tyrosine phosphatase receptor, type r |
| Resolution | 2.3Å |
| Reference | AUTH J.ESWARAN,J.P.VON KRIES,B.MARSDEN,E.LONGMAN,J.E.DEBRECZENI,AUTH 2 E.UGOCHUKWU,A.TURNBULL,W.H.LEE,S.KNAPP,A.J.BARRTITL CRYSTAL STRUCTURES AND INHIBITOR IDENTIFICATION FOR PTPN5,TITL 2 PTPRR AND PTPN7: A FAMILY OF HUMAN MAPK-SPECIFIC PROTEINTITL 3 TYROSINE PHOSPHATASES.REF BIOCHEM.J. V. 395 483 2006REFN ISSN 0264-6021PMID 16441242DOI 10.1042/BJ20051931 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 281 |
| Number Of SNVs | 64 |
| Number Of Permutations | 32876 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.285 |
| p-value | 0.162 |
COSMIC
| Number Of Residues | 281 |
| Number Of SNVs | 9 |
| Number Of Permutations | 6977 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.028 |
| p-value | 0.898 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.027 |
| p-value | 0.781 |