General Structure Information
| PDB ID | 2oo1 |
| HGNC Gene Label(s) | BRD3 |
| Structure Name | crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (brd3) |
| Resolution | 1.7Å |
| Reference | AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 110 |
| Number Of SNVs | 14 |
| Number Of Permutations | 1386 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.055 |
| p-value | 0.912 |
COSMIC
| Number Of Residues | 110 |
| Number Of SNVs | 3 |
| Number Of Permutations | 141 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.744 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.154 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
