General Structure Information
| PDB ID | 1xv9 |
| HGNC Gene Label(s) | NR1I3 |
| Structure Name | crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione. |
| Resolution | 2.7Å |
| Reference | AUTH R.X.XU,M.H.LAMBERT,B.B.WISELY,E.N.WARREN,AUTH 2 E.E.WEINERT,G.M.WAITT,J.D.WILLIAMS,J.L.COLLINS,AUTH 3 L.B.MOORE,T.M.WILLSON,J.T.MOORETITL A STRUCTURAL BASIS FOR CONSTITUTIVE ACTIVITY INTITL 2 THE HUMAN CAR/RXRALPHA HETERODIMER.REF MOL.CELL V. 16 919 2004REFN ISSN 1097-2765PMID 15610735DOI 10.1016/J.MOLCEL.2004.11.042 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 246 |
| Number Of SNVs | 63 |
| Number Of Permutations | 30689 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.01 |
| p-value | 0.01 |
COSMIC
| Number Of Residues | 246 |
| Number Of SNVs | 4 |
| Number Of Permutations | 940 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.167 |
| p-value | 0.939 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 63 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | -0.268 |
| p-value | 0.82 |