3FB2.B | SPTAN1

General Structure Information

PDB ID	3fb2
HGNC Gene Label(s)	SPTAN1
Structure Name	crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a.
Resolution	2.3Å
Reference	AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	194
Number Of SNVs	42
Number Of Permutations	42882
Optimal Distance Threshold	13.0
K Statistic	0.163
p-value	0.291

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:131367728	rs557241146	D>N	B:1340	(53.86, 74.51, 86.44)
9:131367737	rs138827421	R>C	B:1343	(55.55, 76.23, 82.28)
9:131367749	rs574740801	D>N	B:1347	(53.83, 74.45, 75.92)
9:131367750		D>G	B:1347	(53.83, 74.45, 75.92)
9:131367755	COSM1645530 COSM1645529	R>W	B:1349	(48.48, 78.21, 73.99)
9:131367756	rs149367932	R>Q	B:1349	(48.48, 78.21, 73.99)
9:131369903		N>S	B:1356	(46.71, 74.64, 63.02)
9:131369911	rs150944593	R>W	B:1359	(46.38, 70.35, 59.60)
9:131369929	rs144804532	D>Y	B:1365	(43.60, 70.31, 47.04)
9:131369969		L>P	B:1378	(56.65, 65.10, 45.87)
9:131370137		R>W	B:1385	(57.30, 63.78, 57.28)
9:131370169		F>L	B:1395	(54.47, 66.82, 70.13)
9:131370183	rs143108250	Q>L	B:1400	(57.87, 64.15, 80.11)
9:131370185		F>I	B:1401	(55.15, 69.46, 81.72)
9:131370186		F>C	B:1401	(55.15, 69.46, 81.72)
9:131370206	rs181391744	H>N	B:1408	(51.96, 67.06, 90.53)
9:131370209	COSM3996341 COSM203903 COSM3996340	G>R	B:1409	(48.11, 66.31, 91.64)
9:131370222		S>T	B:1413	(44.33, 67.13, 86.23)
9:131370227		E>Q	B:1415	(42.63, 71.58, 81.50)
9:131370234		K>R	B:1417	(43.59, 64.29, 81.94)
9:131370245	COSM3779671 COSM3779670	D>Y	B:1421	(43.33, 63.76, 74.10)
9:131370249	rs140159000	I>T	B:1422	(43.32, 67.81, 72.09)
9:131370263		R>C	B:1427	(51.42, 63.87, 66.68)
9:131370264		R>H	B:1427	(51.42, 63.87, 66.68)
9:131370267	rs143166100	A>G	B:1428	(47.32, 61.78, 64.25)
9:131370287		V>I	B:1435	(49.87, 59.75, 54.30)
9:131370293	rs373033857	R>C	B:1437	(49.15, 66.04, 49.21)
9:131370294		R>H	B:1437	(49.15, 66.04, 49.21)
9:131370313		Q>H	B:1443	(48.22, 58.87, 42.41)
9:131370415		H>D	B:1451	(49.95, 62.46, 30.53)
9:131370419	rs374394049	R>Q	B:1452	(57.09, 61.73, 29.80)
9:131370451	rs565590476	A>T	B:1463	(54.96, 60.99, 11.75)
9:131370544		I>F	B:1494	(57.15, 48.00, 13.81)
9:131370550		V>I	B:1496	(61.06, 49.34, 18.70)
9:131371186		D>N	B:1509	(46.91, 48.07, 32.95)
9:131371188	rs139113273	D>E	B:1509	(46.91, 48.07, 32.95)
9:131371193		L>P	B:1511	(48.03, 53.37, 37.21)
9:131371198		A>T	B:1513	(44.72, 48.37, 39.51)
9:131371201	rs145551982	A>T	B:1514	(45.67, 51.00, 41.94)
9:131371216	rs576419070	K>E	B:1519	(40.53, 54.74, 37.28)
9:131371219	rs374801331 COSM3779677 COSM3779676	G>R	B:1520	(39.56, 56.90, 33.35)
9:131371225		I>V	B:1522	(44.48, 56.35, 32.60)
9:131371228		S>T	B:1523	(41.30, 53.80, 30.29)
9:131371235		R>Q	B:1525	(45.17, 59.42, 26.57)
9:131371241	rs145038571	N>S	B:1527	(41.75, 52.44, 24.94)
9:131371243	COSM1554331 COSM3779678	E>K	B:1528	(42.90, 57.45, 22.10)
9:131371408		R>C	B:1535	(43.29, 52.80, 13.71)
9:131371409		R>H	B:1535	(43.29, 52.80, 13.71)
9:131371436		R>K	B:1544	(56.78, 44.93, 4.58)