General Structure Information
| PDB ID | 3sm9 |
| HGNC Gene Label(s) | GRM3 |
| Structure Name | crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist |
| Resolution | 2.26Å |
| Reference | AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 437 |
| Number Of SNVs | 77 |
| Number Of Permutations | 16410 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.034 |
| p-value | 0.059 |
COSMIC
| Number Of Residues | 437 |
| Number Of SNVs | 23 |
| Number Of Permutations | 27751 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.079 |
| p-value | 0.316 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 26 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.008 |
| p-value | 0.267 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
