General Structure Information
| PDB ID | 2rei |
| HGNC Gene Label(s) | EPHA7 |
| Structure Name | kinase domain of human ephrin type-a receptor 7 (epha7) |
| Resolution | 1.6Å |
| Reference | AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 60 |
| Number Of Permutations | 29788 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.007 |
| p-value | 0.163 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 10 |
| Number Of Permutations | 8450 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.022 |
| p-value | 0.989 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.112 |
| p-value | 0.573 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
