2Y05.C | PTGR1

General Structure Information

PDB ID	2y05
HGNC Gene Label(s)	PTGR1
Structure Name	crystal structure of human leukotriene b4 12-hydroxydehydrogenase in complex with nadp and raloxifene
Resolution	2.2Å
Reference	AUTH W.W.YUE,N.SHAFQAT,T.KROJER,A.C.W.PIKE,F.VON DELFT,R.SETHI,AUTH 2 P.SAVITSKY,C.JOHANSSON,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE B4TITL 2 12-HYDROXYDEHYDROGENASE IN COMPLEX WITH NADP AND RALOXIFENEREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	326
Number Of SNVs	90
Number Of Permutations	41873
Optimal Distance Threshold	10.0
K Statistic	0.06
p-value	0.628

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	90
Number Of COSMIC SNVs	3
Optimal Distance Threshold	33.0
K Statistic	-0.393
p-value	0.511

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:114359654		P>A	C:17	(1.86, 76.53, 49.61)
9:114359650		T>I	C:18	(-0.02, 80.85, 49.69)
9:114359643		S>R	C:20	(1.88, 85.22, 49.24)
9:114359624	rs1053959	A>S	C:27	(13.55, 90.80, 33.43)
9:114359611		P>H	C:31	(22.88, 90.37, 24.53)
9:114359612		P>S	C:31	(22.88, 90.37, 24.53)
9:114356542	rs199615972	L>V	C:38	(16.89, 82.81, 23.67)
9:114356533	rs151088738	A>T	C:41	(8.97, 78.10, 27.40)
9:114356528		L>F	C:42	(7.03, 75.31, 25.04)
9:114356525		F>L	C:43	(5.13, 72.43, 27.43)
9:114356518		V>M	C:46	(5.06, 71.31, 38.78)
9:114356502		R>K	C:51	(7.26, 72.20, 50.30)
9:114355258		A>T	C:53	(13.82, 72.38, 47.76)
9:114355245		L>S	C:57	(15.64, 78.52, 48.04)
9:114355242	rs532658547	K>R	C:58	(17.24, 82.39, 49.35)
9:114355226	rs184433231	M>I	C:63	(11.05, 78.23, 42.26)
9:114355224		M>T	C:64	(13.33, 74.76, 41.79)
9:114348443		V>A	C:71	(16.02, 77.49, 20.13)
9:114348437	rs565921966	E>G	C:73	(17.19, 83.78, 18.58)
9:114348434		S>N	C:74	(21.26, 80.95, 17.74)
9:114348432		K>E	C:75	(25.22, 83.62, 18.58)
9:114348402		V>I	C:85	(15.62, 71.62, 24.63)
9:114348389		P>L	C:89	(15.79, 77.42, 34.08)
9:114348390		P>S	C:89	(15.79, 77.42, 34.08)
9:114348378		T>A	C:93	(9.48, 82.56, 30.16)
9:114348375		H>Y	C:94	(11.90, 83.86, 27.82)
9:114348360		G>R	C:99	(24.32, 74.19, 26.02)
9:114348328		W>C	C:109	(9.85, 62.41, 21.30)
9:114348316	rs538393435	I>M	C:113	(4.15, 62.01, 21.52)
9:114348308	rs375025856	S>C	C:116	(4.98, 67.20, 27.65)
9:114348297		G>R	C:120	(7.16, 62.41, 32.44)
9:114348294		T>P	C:121	(5.86, 59.01, 31.05)
9:114348287		G>A	C:123	(10.84, 61.02, 32.09)
9:114348283		M>I	C:124	(11.69, 62.50, 36.42)
9:114348284		M>R	C:124	(11.69, 62.50, 36.42)
9:114348281		P>R	C:125	(8.45, 60.99, 36.26)
9:114345858	rs557474998	Y>C	C:130	(12.19, 51.39, 34.28)
9:114345856		F>I	C:131	(15.15, 52.62, 37.20)
9:114345817	rs114998608	T>A	C:144	(0.71, 41.66, 44.67)
9:114345808		V>I	C:147	(0.38, 51.92, 44.11)
9:114345796		A>T	C:151	(-3.18, 58.94, 39.47)
9:114345792		G>E	C:152	(-0.03, 60.02, 39.07)
9:114345778	COSM116335	V>I	C:157	(4.00, 54.58, 35.17)
9:114345775	rs193046121	V>M	C:158	(4.19, 51.91, 38.74)
9:114345759	rs147247631	K>M	C:163	(-0.72, 44.87, 34.96)
9:114341221	rs79129665	V>A	C:169	(-2.26, 46.57, 40.62)
9:114341222	rs149744957	V>I	C:169	(-2.26, 46.57, 40.62)
9:114341185		Y>C	C:181	(-7.62, 56.80, 34.10)
9:114341167		F>C	C:187	(-4.67, 49.59, 37.54)
9:114341162	rs150558372	V>I	C:189	(-8.04, 46.92, 43.19)
9:114341159	rs201572502	V>I	C:190	(-8.82, 51.09, 42.47)
9:114341151		N>K	C:192	(-11.16, 56.97, 47.70)
9:114341147	rs141717707	K>E	C:194	(-9.74, 61.08, 50.80)
9:114341143	rs534351470	T>M	C:195	(-14.09, 57.58, 51.04)
9:114341141		V>L	C:196	(-12.45, 54.14, 52.75)
9:114341134		S>F	C:198	(-10.97, 50.64, 56.74)
9:114341122	rs75326768	T>I	C:202	(-9.80, 48.13, 51.89)
9:114341110		A>V	C:206	(-7.56, 43.56, 47.88)
9:114341111	rs201015425 COSM1496991	A>S	C:206	(-7.56, 43.56, 47.88)
9:114341098		G>D	C:210	(-0.95, 40.28, 50.54)
9:114341092		D>G	C:212	(4.67, 40.75, 47.13)
9:114341087		Y>H	C:214	(4.27, 50.21, 49.54)
9:114337119		G>S	C:219	(3.65, 57.78, 53.88)
9:114337116		G>R	C:220	(3.02, 57.54, 57.02)
9:114337113		E>Q	C:221	(-0.26, 56.89, 59.80)
9:114337107		S>T	C:223	(2.75, 53.35, 55.09)
9:114337101		T>A	C:225	(-1.60, 50.56, 57.42)
9:114337098		V>F	C:226	(0.71, 48.97, 53.97)
9:114337092	rs146199919	G>S	C:228	(0.65, 44.98, 57.88)
9:114337062	rs141651182	I>V	C:238	(11.31, 54.54, 50.03)
9:114337046		S>C	C:243	(2.20, 62.93, 53.92)
9:114337044		T>A	C:244	(5.45, 64.60, 55.15)
9:114337029		G>S	C:249	(5.37, 69.37, 62.57)
9:114337022		L>P	C:251	(7.18, 63.19, 61.50)
9:114337023		L>F	C:251	(7.18, 63.19, 61.50)
9:114337020		P>S	C:252	(4.10, 60.68, 61.67)
9:114332487	rs563753365	P>S	C:255	(6.76, 51.84, 61.58)
9:114332484	rs530800998	P>S	C:256	(4.95, 48.72, 63.56)
9:114332480		P>Q	C:257	(8.73, 47.62, 65.24)
9:114332481	rs143051496	P>S	C:257	(8.73, 47.62, 65.24)
9:114332468		I>T	C:261	(11.42, 42.61, 62.84)
9:114332466		Y>H	C:262	(8.29, 39.20, 61.85)
9:114332460		E>K	C:264	(12.07, 39.14, 57.63)
9:114332453	rs149211975	R>H	C:266	(14.15, 45.24, 50.44)
9:114332454	rs376212074 COSM1104069	R>C	C:266	(14.15, 45.24, 50.44)
9:114332451	rs371168547	M>L	C:267	(12.28, 49.13, 53.87)
9:114332441		F>S	C:270	(14.28, 55.50, 44.65)
9:114332436		V>I	C:272	(15.83, 59.20, 39.43)
9:114332429	rs545572614	R>H	C:274	(20.88, 55.39, 41.75)
9:114332430		R>C	C:274	(20.88, 55.39, 41.75)
9:114332418		D>H	C:278	(22.86, 52.82, 28.18)
9:114332412	rs115758301	R>C	C:280	(18.57, 58.43, 31.36)
9:114332402		A>V	C:283	(14.59, 53.46, 29.99)
9:114332397	rs140536268	K>E	C:285	(15.08, 53.95, 24.08)
9:114332379	rs147930843	V>I	C:291	(3.62, 54.89, 24.93)
9:114332373		E>K	C:293	(3.34, 48.96, 22.27)
9:114325444		M>R	C:316	(0.47, 68.81, 42.80)
9:114325445		M>V	C:316	(0.47, 68.81, 42.80)
9:114325417		T>I	C:325	(1.28, 68.56, 36.62)
9:114325415	rs114774740	I>V	C:326	(2.07, 70.21, 32.57)

2Y05.C | PTGR1.

2Y05.C | PTGR1

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:114359624	COSM3763535	A>S	C:27	(13.55, 90.80, 33.43)
9:114345804	COSM4781060	N>S	C:148	(0.73, 55.22, 46.85)
9:114332454	COSM4868925	R>C	C:266	(14.15, 45.24, 50.44)