General Structure Information
| PDB ID | 4ku8 |
| HGNC Gene Label(s) | PRKG1 |
| Structure Name | structures of pkgi reveal a cgmp-selective activation mechanism |
| Resolution | 1.99Å |
| Reference | AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 148 |
| Number Of SNVs | 31 |
| Number Of Permutations | 3958 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.366 |
| p-value | 0.03 |