General Structure Information
| PDB ID | 2p8q |
| HGNC Gene Label(s) | KPNB1 |
| Structure Name | crystal structure of human importin beta bound to the snurportin1 ibb- domain |
| Resolution | 2.35Å |
| Reference | AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 873 |
| Number Of SNVs | 48 |
| Number Of Permutations | 24300 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.186 |
| p-value | 0.024 |
COSMIC
| Number Of Residues | 873 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3368 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.067 |
| p-value | 0.621 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.115 |
| p-value | 0.736 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
