General Structure Information
| PDB ID | 2m0g |
| HGNC Gene Label(s) | SF1 |
| Structure Name | structure, phosphorylation and u2af65 binding of the nterminal domain of splicing factor 1 during 3 splice site recognition |
| Resolution | -1.0Å |
| Reference | AUTH Y.ZHANG,T.MADL,I.BAGDIUL,T.KERN,H.S.KANG,P.ZOU,N.MAUSBACHER,AUTH 2 S.A.SIEBER,A.KRAMER,M.SATTLERTITL STRUCTURE, PHOSPHORYLATION AND U2AF65 BINDING OF THETITL 2 N-TERMINAL DOMAIN OF SPLICING FACTOR 1 DURING 3-SPLICE SITETITL 3 RECOGNITION.REF NUCLEIC ACIDS RES. V. 41 1343 2013REFN ISSN 0305-1048PMID 23175611DOI 10.1093/NAR/GKS1097 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 145 |
| Number Of SNVs | 8 |
| Number Of Permutations | 10839 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.25 |
| p-value | 0.165 |
COSMIC
| Number Of Residues | 145 |
| Number Of SNVs | 5 |
| Number Of Permutations | 170 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.5 |
| p-value | 0.262 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.25 |
| p-value | 0.668 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
