General Structure Information
| PDB ID | 4a4p |
| HGNC Gene Label(s) | CYTH1 |
| Structure Name | crystal structure of the sec7 domain from human cytohesin1 |
| Resolution | 2.0Å |
| Reference | AUTH J.C.ZEEH,A.W.THOMPSON,J.CHERFILS,V.BIOUTITL CRYSTAL STRUCTURE OF THE SEC7 DOMAIN FROM HUMAN CYTOHESIN1REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 186 |
| Number Of SNVs | 41 |
| Number Of Permutations | 5771 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.21 |
| p-value | 0.284 |
COSMIC
| Number Of Residues | 186 |
| Number Of SNVs | 3 |
| Number Of Permutations | 46 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.333 |
| p-value | 0.814 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.485 |
| p-value | 0.229 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
