General Structure Information
| PDB ID | 3mq4 |
| HGNC Gene Label(s) | GRM7 |
| Structure Name | metabotropic glutamate receptor mglur7 complexed with ly341495 antagonist |
| Resolution | 2.8Å |
| Reference | AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,H.HE,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,A.BOCHKAREVTITL MGLUR7 COMPLEXED WITH LY341495REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 386 |
| Number Of SNVs | 67 |
| Number Of Permutations | 16423 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.014 |
| p-value | 0.467 |
COSMIC
| Number Of Residues | 386 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1544 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.2 |
| p-value | 0.738 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.122 |
| p-value | 0.736 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
