General Structure Information
| PDB ID | 2nn6 |
| HGNC Gene Label(s) | EXOSC2 |
| Structure Name | structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 |
| Resolution | 3.35Å |
| Reference | AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 250 |
| Number Of SNVs | 60 |
| Number Of Permutations | 31420 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.033 |
| p-value | 0.295 |
COSMIC
| Number Of Residues | 250 |
| Number Of SNVs | 3 |
| Number Of Permutations | 76 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.667 |
| p-value | 0.505 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.55 |
| p-value | 0.475 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
