General Structure Information
| PDB ID | 2q8h |
| HGNC Gene Label(s) | PDK1 |
| Structure Name | structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) |
| Resolution | 2.0Å |
| Reference | AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 365 |
| Number Of SNVs | 88 |
| Number Of Permutations | 16092 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.055 |
| p-value | 0.297 |
COSMIC
| Number Of Residues | 365 |
| Number Of SNVs | 4 |
| Number Of Permutations | 265 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 88 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.422 |
| p-value | 0.384 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
