General Structure Information
| PDB ID | 3sde |
| HGNC Gene Label(s) | NONO |
| Structure Name | crystal structure of a paraspeckle-protein heterodimer, pspc1/nono |
| Resolution | 1.9Å |
| Reference | AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 239 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2616 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.133 |
| p-value | 0.756 |
COSMIC
| Number Of Residues | 239 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4769 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.286 |
| p-value | 0.344 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 6 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.233 |
| p-value | 0.482 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
