2HYE.C | CUL4A

General Structure Information

PDB ID	2hye
HGNC Gene Label(s)	CUL4A
Structure Name	crystal structure of the ddb1-cul4a-rbx1-sv5v complex
Resolution	3.1Å
Reference	AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175

Variant Set Distributions

ExAC Variants

Number Of Residues	719
Number Of SNVs	127
Number Of Permutations	62921
Optimal Distance Threshold	17.0
K Statistic	0.098
p-value	0.3

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
13:113864353		A>V	C:72	(2.23, 0.98, -101.57)
13:113864371		S>F	C:78	(6.68, -2.49, -103.02)
13:113864377		R>T	C:80	(11.77, 0.81, -105.89)
13:113873266		E>G	C:91	(12.14, 16.30, -90.46)
13:113873287		V>G	C:98	(2.32, 22.61, -93.94)
13:113873295	rs199860261	M>V	C:101	(-2.40, 21.26, -95.22)
13:113873313	rs200825752	R>C	C:107	(-8.06, 11.16, -91.64)
13:113873319		A>S	C:109	(-5.86, 8.34, -97.58)
13:113873323		C>Y	C:110	(-6.80, 6.12, -95.09)
13:113873334		V>I	C:114	(-11.03, 1.80, -95.21)
13:113873344		Q>P	C:117	(-11.04, -2.66, -97.45)
13:113873345	rs199835552	Q>H	C:117	(-11.04, -2.66, -97.45)
13:113873352	rs200624064	P>A	C:120	(-16.05, -6.97, -100.03)
13:113882294		S>A	C:125	(-20.48, -15.87, -99.37)
13:113882307	rs113697945	V>A	C:129	(-15.58, -19.21, -90.69)
13:113882331		T>M	C:137	(-6.60, -10.72, -92.72)
13:113882334		C>Y	C:138	(-8.90, -6.85, -92.75)
13:113882338		W>C	C:139	(-6.92, -5.82, -86.94)
13:113882350		C>W	C:143	(-2.38, -3.22, -88.36)
13:113883760		I>F	C:147	(2.72, -0.03, -88.05)
13:113883767		I>N	C:149	(2.17, 4.92, -92.31)
13:113883811		N>D	C:164	(-3.24, 18.58, -80.73)
13:113883829		I>V	C:170	(-1.17, 8.10, -87.27)
13:113887493		D>G	C:172	(-5.25, 6.18, -82.13)
13:113887498	rs149465391	G>R	C:174	(-7.33, 4.22, -87.70)
13:113887505		E>G	C:176	(-11.58, 7.02, -85.52)
13:113887516		T>A	C:180	(-16.56, 4.33, -88.71)
13:113887517	rs147136485	T>I	C:180	(-16.56, 4.33, -88.71)
13:113887522	rs200368870	I>V	C:182	(-15.23, -2.36, -91.06)
13:113887537	rs372164457	M>V	C:187	(-24.45, -6.07, -92.21)
13:113887539		M>I	C:187	(-24.45, -6.07, -92.21)
13:113887540		V>I	C:188	(-20.11, -6.53, -90.25)
13:113887544	rs376759372	Q>R	C:189	(-21.55, -5.14, -85.41)
13:113887579	rs144303533	E>K	C:201	(-23.06, -21.84, -78.71)
13:113887582		R>C	C:202	(-19.93, -24.51, -82.76)
13:113887583	rs571800452	R>H	C:202	(-19.93, -24.51, -82.76)
13:113887585		E>K	C:203	(-15.40, -24.36, -77.23)
13:113887592	rs147786184	S>N	C:205	(-20.46, -28.18, -77.12)
13:113887594	rs369257799	G>S	C:206	(-17.53, -30.58, -78.72)
13:113887597	COSM3793143 COSM3793142	E>K	C:207	(-17.08, -28.03, -82.19)
13:113887603		V>M	C:209	(-13.23, -23.01, -82.38)
13:113887610		R>Q	C:211	(-8.97, -21.34, -78.19)
13:113887621		R>W	C:215	(-5.69, -14.08, -78.07)
13:113887625		S>I	C:216	(-7.66, -11.76, -82.80)
13:113887634		G>V	C:219	(-9.00, -7.88, -79.42)
13:113887653		Q>H	C:225	(-12.59, 1.52, -77.56)
13:113888232		L>V	C:233	(-24.18, -7.28, -72.90)
13:113888249		E>D	C:238	(-25.78, -16.08, -75.30)
13:113888271		E>K	C:246	(-26.70, -26.91, -68.11)
13:113888286		M>L	C:251	(-30.50, -31.10, -61.26)
13:113888288		M>I	C:251	(-30.50, -31.10, -61.26)
13:113888295		R>G	C:254	(-26.02, -35.96, -65.01)
13:113889383		E>K	C:258	(-22.50, -37.58, -61.53)
13:113889395	rs565872771	H>Y	C:262	(-20.97, -30.17, -65.48)
13:113889407		R>C	C:266	(-19.08, -25.95, -68.04)
13:113889410		L>I	C:267	(-16.15, -23.14, -63.04)
13:113889429		R>K	C:273	(-13.54, -19.79, -72.38)
13:113889431	rs201623121 COSM1365587	V>I	C:274	(-10.51, -15.68, -69.48)
13:113889434	rs557746382	I>V	C:275	(-6.38, -17.41, -69.95)
13:113889459	rs140433067	Q>R	C:283	(-12.78, -14.13, -64.94)
13:113891179		E>D	C:297	(-31.05, -20.39, -58.67)
13:113891202		K>R	C:305	(-31.84, -34.35, -54.76)
13:113893753	rs374255287	D>G	C:308	(-29.02, -37.25, -46.56)
13:113893755		H>N	C:309	(-26.58, -41.12, -50.68)
13:113893756		H>R	C:309	(-26.58, -41.12, -50.68)
13:113893764		D>N	C:312	(-25.64, -42.49, -45.09)
13:113893780	rs151016419	P>L	C:317	(-14.55, -37.43, -52.33)
13:113893788	rs183455854	A>T	C:320	(-15.36, -31.87, -50.95)
13:113893792		Q>R	C:321	(-16.58, -31.27, -55.55)
13:113893802		Q>H	C:324	(-14.21, -26.80, -52.26)
13:113893834	rs140870191	A>V	C:335	(-26.95, -24.21, -46.23)
13:113893840		L>Q	C:337	(-24.18, -25.58, -41.79)
13:113893843		Q>R	C:338	(-29.81, -26.47, -42.39)
13:113893847		H>Q	C:339	(-29.57, -29.53, -44.83)
13:113893851		S>G	C:341	(-27.34, -30.33, -38.57)
13:113893854	COSM945577	E>K	C:342	(-31.84, -31.17, -39.53)
13:113893858		Y>C	C:343	(-27.45, -36.65, -41.35)
13:113897283		T>S	C:346	(-32.18, -37.41, -37.80)
13:113897303	rs375774505	I>V	C:353	(-35.29, -42.67, -28.86)
13:113897322		K>R	C:359	(-27.80, -53.58, -25.16)
13:113897375	rs368810881	E>K	C:377	(-10.41, -34.00, -40.24)
13:113897394		N>S	C:383	(-15.01, -24.74, -40.78)
13:113897399		R>W	C:385	(-18.37, -21.16, -39.75)
13:113897400		R>Q	C:385	(-18.37, -21.16, -39.75)
13:113897405		V>I	C:387	(-16.80, -28.00, -34.90)
13:113897406		V>G	C:387	(-16.80, -28.00, -34.90)
13:113897416	rs377226697	M>I	C:390	(-20.78, -31.56, -33.90)
13:113897433		T>M	C:396	(-29.66, -31.45, -29.22)
13:113897442		N>S	C:399	(-29.82, -34.72, -24.08)
13:113897453		N>D	C:403	(-31.62, -40.44, -17.45)
13:113898748		R>K	C:418	(-15.31, -55.72, -15.50)
13:113898774	rs372924202	E>K	C:427	(-0.50, -46.01, -26.00)
13:113898786		R>W	C:431	(-5.65, -43.39, -28.23)
13:113898790	COSM945580	T>M	C:432	(-10.72, -46.05, -25.70)
13:113898801		I>F	C:436	(-15.70, -42.36, -23.87)
13:113899305		K>R	C:459	(-19.51, -54.49, -7.58)
13:113899352	rs148385873	M>L	C:475	(-11.30, -42.29, -15.68)
13:113899371		H>R	C:481	(-10.19, -31.74, -16.37)
13:113899515	rs375294649	M>I	C:498	(-8.65, -49.98, -0.70)
13:113900270	rs147152451	H>Y	C:511	(-1.09, -58.50, 16.98)
13:113900327		M>V	C:530	(-20.86, -45.66, 5.56)
13:113900349	rs138665383	T>M	C:537	(-28.66, -53.92, 2.67)
13:113907414		V>I	C:553	(-9.97, -60.86, 16.83)
13:113907424		A>V	C:556	(-10.81, -55.59, 18.50)
13:113907496		A>V	C:580	(-12.32, -79.20, -3.35)
13:113909008		G>V	C:585	(-9.17, -83.85, -8.02)
13:113909036		F>L	C:594	(-24.29, -64.97, 0.26)
13:113909043		L>V	C:597	(-22.30, -70.56, 3.71)
13:113909055		M>L	C:601	(-24.70, -77.40, 3.99)
13:113909074	rs142677229	G>A	C:607	(-28.88, -83.71, 0.01)
13:113909098		M>T	C:615	(-33.57, -73.52, 8.12)
13:113909104	COSM945582	T>M	C:617	(-27.37, -70.33, 6.47)
13:113909112		E>K	C:620	(-32.92, -62.90, 1.62)
13:113909270		D>A	C:621	(-36.18, -66.19, -1.98)
13:113909272		S>G	C:622	(-34.13, -62.78, -3.52)
13:113909282		R>H	C:625	(-34.55, -68.56, -5.50)
13:113909288		T>M	C:627	(-26.81, -67.86, -4.83)
13:113909299	COSM160279	L>V	C:631	(-23.68, -73.64, -7.60)
13:113909302		A>S	C:632	(-26.27, -75.19, -11.07)
13:113909306		C>F	C:633	(-28.42, -74.07, -13.56)
13:113909312		K>R	C:635	(-21.28, -73.98, -16.30)
13:113909318		R>H	C:637	(-19.05, -77.51, -14.26)
13:113909320		V>M	C:638	(-20.89, -77.86, -8.38)
13:113909339	rs2302757	K>R	C:644	(-33.30, -80.19, -14.80)
13:113909359		G>R	C:651	(-38.06, -78.28, -3.40)
13:113909380		G>R	C:658	(-18.68, -85.47, -9.45)
13:113909402	COSM1202686	F>C	C:665	(-6.67, -76.05, -9.24)
13:113914949	rs139078644	R>K	C:687	(-30.86, -44.09, -3.02)
13:113914970	COSM3813469 COSM3813468	Y>C	C:694	(-32.24, -33.53, -0.77)
13:113914987		I>V	C:700	(-30.75, -22.73, -4.13)
13:113917802	rs201177759	P>L	C:729	(-39.56, -26.14, -14.14)
13:113917810	rs144019898	L>M	C:732	(-37.27, -24.59, -8.98)
13:113917874		N>S	C:753	(-39.62, -12.11, -10.72)
13:113917877		Q>R	C:754	(-36.80, -9.41, -7.20)
13:113917888	rs370203390	V>M	C:758	(-33.41, -14.03, 4.70)