4MP7.A | PDK2

General Structure Information

PDB ID 4mp7
HGNC Gene Label(s) PDK2
Structure Name crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7
Resolution 1.8Å
Reference AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885

Variant Set Distributions

ExAC Variants

Number Of Residues 363
Number Of SNVs 75
Number Of Permutations 39435
Optimal Distance Threshold 15.0
K Statistic 0.116
p-value 0.158

Mapped Variants

[+] ExAC Missense Variants