General Structure Information
| PDB ID | 1bwn |
| HGNC Gene Label(s) | BTK |
| Structure Name | ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 |
| Resolution | 2.1Å |
| Reference | AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 161 |
| Number Of SNVs | 9 |
| Number Of Permutations | 758 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.0 |
| p-value | 0.767 |
ClinVar
| Number Of Residues | 161 |
| Number Of SNVs | 3 |
| Number Of Permutations | 107 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.682 |
COSMIC
| Number Of Residues | 161 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 9 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.111 |
| p-value | 0.717 |
Cosmic vs. ExAC
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
