General Structure Information
| PDB ID | 4a11 |
| HGNC Gene Label(s) | ERCC8 |
| Structure Name | structure of the hsddb1-hscsa complex |
| Resolution | 3.31Å |
| Reference | AUTH E.S.FISCHER,A.SCRIMA,K.BOHM,S.MATSUMOTO,G.M.LINGARAJU,AUTH 2 M.FATY,T.YASUDA,S.CAVADINI,M.WAKASUGI,F.HANAOKA,S.IWAI,AUTH 3 H.GUT,K.SUGASAWA,N.H.THOMATITL THE MOLECULAR BASIS OF CRL4(DDB2/CSA) UBIQUITIN LIGASETITL 2 ARCHITECTURE, TARGETING, AND ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 147 1024 2011REFN ISSN 0092-8674PMID 22118460DOI 10.1016/J.CELL.2011.10.035 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 365 |
| Number Of SNVs | 98 |
| Number Of Permutations | 46473 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.267 |
| p-value | 0.215 |
ClinVar
| Number Of Residues | 365 |
| Number Of SNVs | 4 |
| Number Of Permutations | 861 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.231 |
COSMIC
| Number Of Residues | 365 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2874 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.067 |
| p-value | 0.915 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.251 |
| p-value | 0.228 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.082 |
| p-value | 0.948 |