General Structure Information
| PDB ID | 4ny0 |
| HGNC Gene Label(s) | PTK2 |
| Structure Name | crystal structure of ferm domain of human focal adhesion kinase |
| Resolution | 2.8Å |
| Reference | AUTH K.BRAMI-CHERRIER,N.GERVASI,D.ARSENIEVA,K.WALKIEWICZ,AUTH 2 M.C.BOUTTERIN,A.ORTEGA,P.G.LEONARD,B.SEANTIER,L.GASMI,AUTH 3 T.BOUCEBA,G.KADARE,J.A.GIRAULT,S.T.AROLDTITL FAK DIMERIZATION CONTROLS ITS KINASE-DEPENDENT FUNCTIONS ATTITL 2 FOCAL ADHESIONS.REF EMBO J. V. 33 356 2014REFN ISSN 0261-4189PMID 24480479DOI 10.1002/EMBJ.201386399 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 56 |
| Number Of Permutations | 10106 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.144 |
| p-value | 0.38 |
COSMIC
| Number Of Residues | 329 |
| Number Of SNVs | 6 |
| Number Of Permutations | 504 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.467 |
| p-value | 0.335 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.364 |
| p-value | 0.281 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
