4GNK.B | PLCB3

General Structure Information

PDB ID	4gnk
HGNC Gene Label(s)	PLCB3
Structure Name	crystal structure of galphaq in complex with full-length human plcbeta3
Resolution	4.0Å
Reference	AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497

Variant Set Distributions

ExAC Variants

Number Of Residues	769
Number Of SNVs	136
Number Of Permutations	84329
Optimal Distance Threshold	16.0
K Statistic	0.064
p-value	0.014

COSMIC

Number Of Residues	769
Number Of SNVs	13
Number Of Permutations	15213
Optimal Distance Threshold	10.0
K Statistic	0.038
p-value	0.949

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	136
Number Of COSMIC SNVs	12
Optimal Distance Threshold	13.0
K Statistic	0.037
p-value	0.358

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:64019218	rs189178959	E>Q	B:33	(-52.69, -2.67, -2.31)
11:64021890		T>A	B:35	(-47.88, -7.60, -0.33)
11:64021899		R>W	B:38	(-47.09, -1.09, 5.98)
11:64021918	COSM930043	R>H	B:44	(-29.94, 7.24, -2.51)
11:64021930	rs111961110	N>S	B:48	(-24.40, 10.13, -14.71)
11:64021951		T>M	B:55	(-32.28, -0.33, 0.88)
11:64021960		N>S	B:58	(-34.63, -8.48, 1.40)
11:64022226		D>N	B:62	(-34.22, -3.23, -5.24)
11:64022260		R>Q	B:73	(-49.06, 9.76, -12.08)
11:64022269	rs371998747 COSM429524	R>Q	B:76	(-55.33, 16.16, -8.02)
11:64022271		Y>N	B:77	(-53.84, 14.44, -11.17)
11:64022283	rs369122916	P>T	B:81	(-54.95, 3.77, -1.18)
11:64022373		P>S	B:84	(-59.44, -0.55, 4.09)
11:64022382	rs201041817	R>W	B:87	(-57.44, 4.34, 2.67)
11:64022404	rs143389743	G>D	B:94	(-57.22, 11.51, 10.07)
11:64022409		D>N	B:96	(-53.49, 16.26, 8.59)
11:64022415		R>W	B:98	(-49.75, 18.54, 3.55)
11:64022416		R>L	B:98	(-49.75, 18.54, 3.55)
11:64022437	rs540937471 COSM1220915	T>M	B:105	(-47.20, 7.43, -8.40)
11:64022490		V>M	B:123	(-41.02, 12.53, 5.50)
11:64022506		A>V	B:128	(-42.82, 14.84, -2.98)
11:64022757		A>T	B:147	(-26.98, 8.43, -26.12)
11:64022769		T>S	B:151	(-23.16, 6.60, -21.99)
11:64022778		R>C	B:154	(-20.58, 5.35, -18.75)
11:64022779		R>H	B:154	(-20.58, 5.35, -18.75)
11:64022785	rs144191345	A>V	B:156	(-23.62, -1.37, -17.15)
11:64022873	rs199645363 COSM3687470	T>M	B:158	(-24.02, 1.94, -12.68)
11:64022905	rs138400940	R>W	B:169	(-18.26, -7.74, -0.90)
11:64022906		R>Q	B:169	(-18.26, -7.74, -0.90)
11:64023032	rs376722661	A>T	B:181	(-22.72, -15.19, -23.61)
11:64023057		A>V	B:189	(-10.93, -11.76, -17.46)
11:64023196		E>K	B:201	(-17.91, -16.28, -5.66)
11:64023205		R>W	B:204	(-13.01, -4.70, -2.30)
11:64023239		R>Q	B:215	(-7.51, -2.18, -18.19)
11:64023248		N>S	B:218	(-10.69, -4.21, -23.83)
11:64023266		P>Q	B:224	(-11.86, -8.25, -34.93)
11:64023874		T>M	B:242	(-1.62, 10.27, -37.52)
11:64023889		M>R	B:247	(-8.48, 15.30, -40.47)
11:64023891	rs149333155	D>N	B:248	(-8.10, 13.03, -43.74)
11:64023904	rs61734557	Q>R	B:252	(-12.45, 10.98, -46.83)
11:64023907		K>R	B:253	(-15.15, 7.77, -45.09)
11:64023912		R>C	B:255	(-18.55, 15.29, -43.93)
11:64023913		R>H	B:255	(-18.55, 15.29, -43.93)
11:64023943		P>L	B:265	(-17.78, 22.78, -41.52)
11:64023951		R>W	B:268	(-11.20, 23.09, -38.81)
11:64023967		R>Q	B:273	(-4.67, 18.91, -30.92)
11:64024000		Q>R	B:284	(3.57, 7.52, -24.04)
11:64024012		R>Q	B:288	(4.44, 10.56, -29.21)
11:64024107		G>S	B:295	(-9.25, 5.38, -28.50)
11:64024116		R>C	B:298	(-12.42, 5.26, -25.56)
11:64024117		R>H	B:298	(-12.42, 5.26, -25.56)
11:64024132		E>A	B:303	(-20.12, 11.77, -26.99)
11:64024149	rs554380791	P>S	B:309	(-28.16, 14.30, -36.32)
11:64024158		A>T	B:312	(-33.27, 15.35, -35.80)
11:64024164		D>N	B:314	(-34.68, 19.36, -31.80)
11:64024174	rs372605260	T>M	B:317	(-39.67, 21.25, -37.73)
11:64024233		T>A	B:337	(-56.27, -2.65, -23.14)
11:64025969		S>L	B:346	(-58.60, 1.65, -19.21)
11:64025983		R>C	B:351	(-53.73, 8.73, -17.53)
11:64026041	rs202112716	P>L	B:370	(-81.69, 4.06, -15.59)
11:64026043		P>S	B:371	(-80.39, 4.36, -12.16)
11:64026094		P>A	B:388	(-66.12, 6.16, -16.66)
11:64026095		P>H	B:388	(-66.12, 6.16, -16.66)
11:64026103		D>N	B:391	(-62.70, 9.09, -14.69)
11:64026143	COSM1220914	S>L	B:404	(-46.41, 17.70, -26.37)
11:64026145	COSM544305	P>A	B:405	(-46.42, 21.43, -26.17)
11:64026152		P>L	B:407	(-52.34, 20.58, -30.71)
11:64026154	rs145872781	V>I	B:408	(-55.09, 17.38, -28.60)
11:64026169		E>K	B:413	(-67.58, 7.19, -32.03)
11:64026176		H>R	B:415	(-73.07, 6.17, -30.12)
11:64026184		S>P	B:418	(-79.99, 12.33, -24.56)
11:64026185	rs371015701	S>L	B:418	(-79.99, 12.33, -24.56)
11:64026370		A>T	B:423	(-75.46, 18.39, -22.04)
11:64026371		A>E	B:423	(-75.46, 18.39, -22.04)
11:64026391	rs141811797	R>C	B:430	(-67.66, 24.30, -21.63)
11:64026392		R>H	B:430	(-67.66, 24.30, -21.63)
11:64026397	rs576970524	I>V	B:432	(-62.48, 18.90, -16.96)
11:64026404	rs201844304	G>E	B:434	(-61.42, 24.91, -19.95)
11:64026406		D>N	B:435	(-59.00, 28.03, -20.56)
11:64026421		E>K	B:440	(-65.35, 30.81, -29.70)
11:64026430		D>N	B:443	(-60.00, 36.56, -34.18)
11:64026439		P>S	B:446	(-61.83, 32.57, -40.04)
11:64026534		A>V	B:448	(-64.30, 30.36, -44.24)
11:64026542		V>I	B:451	(-59.89, 30.14, -44.49)
11:64026561		Q>R	B:457	(-47.11, 27.81, -33.05)
11:64026572		G>C	B:461	(-52.70, 23.96, -25.62)
11:64026575		R>C	B:462	(-56.28, 25.52, -27.15)
11:64028899		T>A	B:587	(-77.17, 18.04, -30.02)
11:64028915		T>K	B:592	(-70.69, 24.93, -29.59)
11:64028921		V>D	B:594	(-67.36, 21.78, -33.25)
11:64028929		I>V	B:597	(-61.88, 19.20, -36.51)
11:64028947	rs143280611	K>E	B:603	(-70.33, 13.49, -51.54)
11:64028954		F>Y	B:605	(-61.47, 13.40, -53.66)
11:64028966		R>Q	B:609	(-60.89, 20.05, -54.90)
11:64029056		R>K	B:611	(-68.01, 22.71, -49.68)
11:64029060		N>K	B:612	(-62.78, 26.11, -50.93)
11:64029091		T>P	B:623	(-61.27, -0.83, -46.96)
11:64029100		M>V	B:626	(-56.72, 0.92, -49.92)
11:64029101		M>T	B:626	(-56.72, 0.92, -49.92)
11:64029125		M>T	B:634	(-52.92, 12.22, -58.34)
11:64029137		E>A	B:638	(-54.32, 17.87, -55.15)
11:64029434		Q>K	B:642	(-56.83, 21.99, -49.39)
11:64029468	COSM930054	R>H	B:653	(-57.41, -5.48, -38.44)
11:64029470		V>M	B:654	(-60.99, -8.91, -33.91)
11:64029490		M>I	B:660	(-48.28, -0.23, -42.97)
11:64029496	rs540587716	Q>H	B:662	(-45.78, 4.65, -45.18)
11:64029545		L>F	B:679	(-46.27, -2.99, -30.13)
11:64029881	rs527496239	V>M	B:681	(-44.12, -3.93, -37.92)
11:64029900	rs369907605	A>V	B:687	(-43.07, 4.92, -32.61)
11:64029905	COSM3375899	V>I	B:689	(-41.42, 8.10, -36.82)
11:64029920		G>R	B:694	(-39.49, 16.25, -30.07)
11:64029923	COSM3687472	R>C	B:695	(-40.20, 12.68, -27.79)
11:64029924		R>H	B:695	(-40.20, 12.68, -27.79)
11:64029956	COSM1676138	R>W	B:706	(-46.19, 21.26, -47.74)
11:64029962		P>S	B:708	(-50.28, 24.37, -54.05)
11:64029963	rs377220651	P>L	B:708	(-50.28, 24.37, -54.05)
11:64029980		P>A	B:714	(-47.54, 8.63, -55.42)
11:64029990		E>G	B:717	(-41.72, 3.51, -61.82)
11:64029997	rs145953984	I>M	B:719	(-36.26, 10.85, -61.04)
11:64029998		V>M	B:720	(-39.38, 13.75, -59.35)
11:64030007		I>V	B:723	(-37.59, 15.70, -55.59)
11:64030025		R>W	B:729	(-23.83, 1.19, -50.05)
11:64030119	rs370898239	V>M	B:732	(-23.91, -5.19, -41.32)
11:64030143		D>N	B:740	(-29.24, -12.85, -21.66)
11:64030147		R>K	B:741	(-30.25, -16.91, -24.80)
11:64030159		I>T	B:745	(-27.85, -13.17, -33.88)
11:64030198		T>M	B:758	(-40.62, 0.04, -50.31)
11:64030203	rs201470515	R>C	B:760	(-40.56, -5.27, -45.90)
11:64030212		R>C	B:763	(-31.74, -12.44, -43.56)
11:64030237		S>L	B:771	(-24.26, -13.59, -28.44)
11:64030257		E>K	B:778	(-22.75, -9.82, -45.20)
11:64030269		D>N	B:782	(-27.40, -1.56, -52.22)
11:64031019		G>A	B:802	(-36.57, -18.19, -34.52)
11:64031030	rs145502455	V>I	B:806	(-33.30, -8.54, -29.79)
11:64031055		S>F	B:814	(-33.05, 12.40, -44.49)
11:64031057		A>P	B:815	(-30.39, 12.43, -41.46)
11:64031063	rs199676501	R>C	B:817	(-24.39, 11.51, -39.16)
11:64031174	rs372712260	V>I	B:823	(-27.00, 1.38, -34.00)
11:64031202		P>L	B:832	(-33.61, 2.77, -24.27)
11:64031241	rs35169799	S>L	B:845	(-25.66, 9.76, -51.78)
11:64031249	rs200176343	I>V	B:848	(-25.66, 10.64, -59.94)
11:64031258	rs369369040 COSM2163262	D>N	B:851	(-26.66, 7.64, -68.46)
11:64031267		D>H	B:854	(-18.95, 11.77, -66.83)
11:64031499	COSM930058	A>V	B:856	(-21.90, 15.43, -62.67)
11:64031528		V>I	B:866	(-12.32, 23.26, -69.14)
11:64031550		A>V	B:873	(-8.41, 20.64, -78.84)
11:64031552		R>G	B:874	(-4.58, 23.38, -76.82)
11:64031553		R>Q	B:874	(-4.58, 23.38, -76.82)
11:64031571	rs200263631	I>T	B:880	(-6.79, 19.50, -88.57)

4GNK.B | PLCB3.

4GNK.B | PLCB3

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:64021917	COSM1241586	R>C	B:44	(-29.94, 7.24, -2.51)
11:64022437	COSM1220915	T>M	B:105	(-47.20, 7.43, -8.40)
11:64023238	COSM317885	R>W	B:215	(-7.51, -2.18, -18.19)
11:64024111	COSM1676137	F>C	B:296	(-10.67, 4.36, -33.42)
11:64026008	COSM930050	R>H	B:359	(-51.14, 14.83, -29.32)
11:64026040	COSM4035078	P>S	B:370	(-81.69, 4.06, -15.59)
11:64026143	COSM1220914	S>L	B:404	(-46.41, 17.70, -26.37)
11:64026164	COSM3451396	S>F	B:411	(-62.48, 11.47, -31.80)
11:64029923	COSM3687472	R>C	B:695	(-40.20, 12.68, -27.79)
11:64029959	COSM1355656	R>W	B:707	(-45.64, 23.69, -53.04)
11:64030200	COSM1676139	R>W	B:759	(-36.23, -2.07, -51.68)
11:64031166	COSM1604954	Y>F	B:820	(-17.07, 2.73, -40.46)
11:64031499	COSM930058	A>V	B:856	(-21.90, 15.43, -62.67)