General Structure Information
| PDB ID | 4or2 |
| HGNC Gene Label(s) | GRM1 |
| Structure Name | human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator |
| Resolution | 2.8Å |
| Reference | AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 261 |
| Number Of SNVs | 33 |
| Number Of Permutations | 28050 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.309 |
| p-value | 0.139 |
COSMIC
| Number Of Residues | 261 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1524 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.048 |
| p-value | 0.422 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.445 |
| p-value | 0.146 |