General Structure Information
| PDB ID | 4bgg |
| HGNC Gene Label(s) | ACVR1 |
| Structure Name | crystal structure of the acvr1 kinase in complex with ldn-213844 |
| Resolution | 2.56Å |
| Reference | AUTH A.H.MOHEDAS,Y.WANG,C.E.SANVITALE,P.CANNING,S.CHOI,X.XING,AUTH 2 A.N.BULLOCK,G.D.CUNY,P.B.YUTITL STRUCTURE-ACTIVITY RELATIONSHIP OF 3,5-DIARYL-2-TITL 2 AMINOPYRIDINE ALK2 INHIBITORS REVEALS UNALTERED BINDINGTITL 3 AFFINITY FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA CAUSINGTITL 4 MUTANTS.REF J.MED.CHEM. V. 57 7900 2014REFN ISSN 0022-2623PMID 25101911DOI 10.1021/JM501177W |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 296 |
| Number Of SNVs | 40 |
| Number Of Permutations | 6460 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.023 |
| p-value | 0.522 |
ClinVar
| Number Of Residues | 296 |
| Number Of SNVs | 3 |
| Number Of Permutations | 177 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.0 |
| p-value | 0.598 |
COSMIC
| Number Of Residues | 296 |
| Number Of SNVs | 5 |
| Number Of Permutations | 146 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.1 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.272 |
| p-value | 0.01 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.179 |
| p-value | 0.878 |