General Structure Information
| PDB ID | 2aze |
| HGNC Gene Label(s) | E2F1 |
| Structure Name | structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer |
| Resolution | 2.55Å |
| Reference | AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 101 |
| Number Of SNVs | 20 |
| Number Of Permutations | 12773 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.2 |
| p-value | 0.082 |
COSMIC
| Number Of Residues | 101 |
| Number Of SNVs | 3 |
| Number Of Permutations | 161 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.667 |
| p-value | 0.124 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 20 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.747 |
| p-value | 0.124 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
