1SD1.A | MTAP – ASTRID

1SD1.A | MTAP

General Structure Information

PDB ID	1sd1
HGNC Gene Label(s)	MTAP
Structure Name	structure of human 5-deoxy-5-methylthioadenosine phosphorylase complexed with formycin a
Resolution	2.03Å
Reference	AUTH J.E.LEE,E.C.SETTEMBRE,K.A.CORNELL,M.K.RISCOE,J.R.SUFRIN,AUTH 2 S.E.EALICK,P.L.HOWELLTITL STRUCTURAL COMPARISON OF MTA PHOSPHORYLASE AND MTA/ADOHCYTITL 2 NUCLEOSIDASE EXPLAINS SUBSTRATE PREFERENCES AND IDENTIFIESTITL 3 REGIONS EXPLOITABLE FOR INHIBITOR DESIGN.REF BIOCHEMISTRY V. 43 5159 2004REFN ISSN 0006-2960PMID 15122881DOI 10.1021/BI035492H

Variant Set Distributions

ExAC Variants

Number Of Residues	268
Number Of SNVs	91
Number Of Permutations	26816
Optimal Distance Threshold	12.0
K Statistic	0.126
p-value	0.525

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:21802775		V>M	A:10	(90.00, 13.05, 33.86)
9:21815441		I>V	A:15	(73.76, 14.88, 35.13)
9:21815444	rs368005706	G>S	A:16	(70.68, 12.03, 34.92)
9:21815448	rs543320391	G>E	A:17	(67.74, 11.62, 33.54)
9:21815460		D>V	A:21	(69.34, 7.62, 36.29)
9:21815507	rs373606947	P>A	A:37	(77.21, 26.87, 49.05)
9:21815514		G>V	A:39	(72.75, 23.41, 48.75)
9:21815516		K>Q	A:40	(71.07, 19.59, 50.12)
9:21815517		K>M	A:40	(71.07, 19.59, 50.12)
9:21816728		I>L	A:46	(77.08, 7.58, 42.84)
9:21816738		K>R	A:49	(86.19, 3.57, 38.35)
9:21816749		V>F	A:53	(87.68, 6.79, 34.15)
9:21816758	rs7023954	V>I	A:56	(80.49, 11.52, 39.66)
9:21818036		H>R	A:61	(64.75, 15.14, 38.03)
9:21818044		Q>K	A:64	(62.34, 8.40, 44.33)
9:21818049		H>Q	A:65	(61.39, 12.04, 38.74)
9:21818054	rs143281052	I>N	A:67	(62.85, 17.22, 41.55)
9:21818066		K>R	A:71	(61.53, 23.51, 41.91)
9:21818068		V>F	A:72	(66.40, 21.35, 39.72)
9:21818078		Q>R	A:75	(73.12, 26.82, 41.81)
9:21818081		A>V	A:76	(74.23, 22.30, 43.68)
9:21818086		I>F	A:78	(77.28, 22.06, 38.69)
9:21818093		A>G	A:80	(79.18, 19.14, 43.65)
9:21818102		E>A	A:83	(84.25, 20.57, 45.57)
9:21818107		G>R	A:85	(86.76, 17.07, 40.45)
9:21818113		T>A	A:87	(87.11, 17.69, 34.37)
9:21818117		H>R	A:88	(85.05, 16.41, 31.64)
9:21818125		V>L	A:91	(74.25, 15.17, 30.40)
9:21818129		T>I	A:92	(71.21, 12.37, 30.01)
9:21818132		T>I	A:93	(68.03, 14.86, 27.94)
9:21818144	rs200687016	S>Y	A:97	(61.44, 16.59, 17.61)
9:21818167	rs540813749	G>S	A:105	(65.77, 7.56, 19.32)
9:21818183		I>T	A:110	(73.08, 19.65, 21.92)
9:21818185		D>H	A:111	(75.48, 23.11, 19.16)
9:21818200		R>G	A:116	(60.60, 30.46, 26.37)
9:21837911		T>S	A:118	(61.25, 32.32, 33.76)
9:21837914		M>V	A:119	(61.16, 30.65, 37.63)
9:21837927	COSM753754	S>C	A:123	(74.85, 32.54, 38.51)
9:21837931		F>L	A:124	(77.52, 29.49, 40.72)
9:21837933		Y>S	A:125	(79.77, 34.51, 40.52)
9:21837950		C>R	A:131	(82.21, 31.04, 46.86)
9:21837951	rs371627007	C>F	A:131	(82.21, 31.04, 46.86)
9:21837958	rs201264519	R>S	A:133	(83.86, 37.26, 46.08)
9:21837962		V>M	A:135	(79.45, 40.40, 38.46)
9:21837973		I>M	A:138	(79.60, 33.42, 31.15)
9:21837977		M>V	A:140	(77.14, 31.10, 26.36)
9:21837981		A>V	A:141	(78.91, 31.24, 21.91)
9:21837987		P>L	A:143	(77.51, 26.58, 24.91)
9:21838002	rs368718537	T>M	A:148	(83.29, 16.30, 24.58)
9:21854637		I>T	A:153	(79.84, 12.59, 17.20)
9:21854641		E>D	A:154	(83.53, 8.80, 16.13)
9:21854649		K>R	A:157	(80.60, 6.52, 13.23)
9:21854663	rs541314246	R>W	A:162	(69.41, 7.35, 13.65)
9:21854664	rs143597255	R>Q	A:162	(69.41, 7.35, 13.65)
9:21854684	rs529690040	M>V	A:169	(67.73, 22.32, 23.21)
9:21854705	rs569692278	R>C	A:176	(53.54, 24.41, 29.83)
9:21854715		S>Y	A:179	(51.55, 25.17, 22.53)
9:21854729	rs148068697	F>V	A:184	(53.88, 25.40, 14.70)
9:21854735		F>I	A:186	(59.65, 27.19, 19.95)
9:21854738		R>C	A:187	(59.68, 24.24, 13.32)
9:21854739	rs147028761	R>H	A:187	(59.68, 24.24, 13.32)
9:21854748	rs143891667	G>E	A:190	(65.67, 27.08, 15.03)
9:21854751	rs200708704 COSM1461796	A>V	A:191	(64.63, 24.92, 17.03)
9:21854759	rs150641573	I>V	A:194	(61.87, 20.83, 23.28)
9:21854769	rs138887943	T>S	A:197	(66.84, 20.60, 31.92)
9:21854774		V>I	A:199	(68.75, 26.26, 30.67)
9:21854786		V>L	A:203	(75.29, 28.42, 32.16)
9:21854808	rs375453271	I>S	A:210	(83.08, 22.09, 33.80)
9:21854809		I>M	A:210	(83.08, 22.09, 33.80)
9:21854811		C>S	A:211	(83.92, 20.21, 30.01)
9:21854816	rs369819046	A>T	A:213	(78.00, 17.59, 27.28)
9:21854819	rs577238120	S>G	A:214	(74.22, 16.86, 25.88)
9:21854825	rs202130608	A>T	A:216	(69.89, 14.15, 23.33)
9:21854826		A>G	A:216	(69.89, 14.15, 23.33)
9:21854828		M>V	A:217	(67.07, 10.50, 23.35)
9:21854832	rs143080527	A>V	A:218	(64.38, 11.73, 21.03)
9:21854840	rs138566956	Y>D	A:221	(58.27, 13.99, 16.06)
9:21859308		V>L	A:233	(54.28, 11.42, 30.34)
9:21859314		R>W	A:235	(55.60, 7.73, 23.65)
9:21859317	rs139815499	V>I	A:236	(58.41, 10.29, 27.11)
9:21859341		A>T	A:244	(68.32, 3.70, 27.49)
9:21859359		L>I	A:250	(77.53, 6.79, 24.05)
9:21859366		L>P	A:252	(80.14, 2.70, 29.01)
9:21859368		T>A	A:253	(82.38, 3.69, 24.67)
9:21859369		T>N	A:253	(82.38, 3.69, 24.67)
9:21859372		T>S	A:254	(82.83, 8.10, 25.30)
9:21859381		Q>R	A:257	(88.70, 7.87, 23.92)
9:21859383	rs181734039	I>V	A:258	(87.51, 11.44, 27.47)
9:21859389		S>P	A:260	(92.91, 8.65, 26.20)
9:21859399	rs373274501	W>L	A:263	(90.53, 16.87, 27.56)
9:21931010		I>L	A:273	(86.27, 32.06, 29.38)
9:21931015		K>N	A:274	(85.68, 32.08, 33.89)
9:21931016	rs370690251	F>L	A:275	(89.59, 34.10, 36.10)
9:21931020	rs73652803	Q>R	A:276	(89.84, 36.44, 32.67)
9:21931024		M>I	A:277	(83.88, 36.60, 33.24)
9:21931025		I>V	A:278	(84.51, 37.86, 37.27)
9:21931026	rs371711818	I>T	A:278	(84.51, 37.86, 37.27)
9:21931032	rs138849306	S>T	A:280	(86.12, 41.88, 41.33)
9:21931034		E>K	A:281	(84.73, 44.74, 43.74)