General Structure Information
| PDB ID | 2w5z |
| HGNC Gene Label(s) | KMT2A |
| Structure Name | ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. |
| Resolution | 2.2Å |
| Reference | AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 180 |
| Number Of SNVs | 17 |
| Number Of Permutations | 6696 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.272 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 180 |
| Number Of SNVs | 3 |
| Number Of Permutations | 189 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.237 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 17 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.319 |
| p-value | 0.505 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
