General Structure Information
| PDB ID | 3bxm |
| HGNC Gene Label(s) | FOLH1 |
| Structure Name | structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) |
| Resolution | 1.71Å |
| Reference | AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 694 |
| Number Of SNVs | 97 |
| Number Of Permutations | 27405 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.31 |
| p-value | 0.009 |
COSMIC
| Number Of Residues | 694 |
| Number Of SNVs | 16 |
| Number Of Permutations | 4660 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.058 |
| p-value | 0.824 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.157 |
| p-value | 0.321 |