4GT4.B | ROR2 – ASTRID

4GT4.B | ROR2

General Structure Information

PDB ID	4gt4
HGNC Gene Label(s)	ROR2
Structure Name	structure of unliganded, inactive ror2 kinase domain
Resolution	2.41Å
Reference	AUTH S.C.ARTIM,J.M.MENDROLA,M.A.LEMMONTITL ASSESSING THE RANGE OF KINASE AUTOINHIBITION MECHANISMS INTITL 2 THE INSULIN RECEPTOR FAMILY.REF BIOCHEM.J. V. 448 213 2012REFN ISSN 0264-6021PMID 22992069DOI 10.1042/BJ20121365

Variant Set Distributions

ExAC Variants

Number Of Residues	273
Number Of SNVs	99
Number Of Permutations	31656
Optimal Distance Threshold	10.0
K Statistic	0.047
p-value	0.0

COSMIC

Number Of Residues	273
Number Of SNVs	12
Number Of Permutations	6560
Optimal Distance Threshold	10.0
K Statistic	0.015
p-value	0.786

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	99
Number Of COSMIC SNVs	10
Optimal Distance Threshold	22.0
K Statistic	0.179
p-value	0.22

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:94487385	rs370381490 COSM95205	K>R	B:464	(-36.31, -31.50, 12.35)
9:94487377	COSM1111031	E>Q	B:467	(-31.42, -39.26, 7.77)
9:94487374	COSM1701317	I>L	B:468	(-33.88, -40.88, 4.22)
9:94487361	COSM379481	A>V	B:472	(-35.35, -46.43, 0.27)
9:94487348		M>I	B:476	(-36.57, -42.72, -11.66)
9:94487350	rs200274070	M>V	B:476	(-36.57, -42.72, -11.66)
9:94487332		D>H	B:482	(-30.74, -26.88, -9.02)
9:94487328	COSM456220	R>Q	B:483	(-28.22, -22.71, -6.55)
9:94487319		K>T	B:486	(-29.43, -32.43, -10.69)
9:94487309		K>N	B:489	(-37.47, -38.76, -10.34)
9:94487307	rs56197744	G>A	B:490	(-38.92, -41.00, -7.62)
9:94487274	rs142047260	T>N	B:501	(-44.64, -46.40, -2.19)
9:94487263		A>T	B:505	(-38.22, -35.25, -5.41)
9:94487253	rs148289272	T>M	B:508	(-28.82, -33.67, -6.23)
9:94487254		T>A	B:508	(-28.82, -33.67, -6.23)
9:94487230		P>S	B:516	(-19.16, -23.37, 0.16)
9:94487224	rs148896640	R>W	B:518	(-20.69, -28.59, 1.28)
9:94487216		E>D	B:520	(-26.23, -23.56, 1.18)
9:94487211	rs201986784	R>Q	B:522	(-27.17, -28.03, 4.55)
9:94487212		R>W	B:522	(-27.17, -28.03, 4.55)
9:94487202	rs34584753	A>G	B:525	(-32.73, -27.76, 4.11)
9:94487193	rs142215888	R>Q	B:528	(-38.53, -26.20, 2.28)
9:94487187	rs35852786	R>Q	B:530	(-38.19, -24.22, 9.50)
9:94487188	rs369080860 COSM1663950	R>W	B:530	(-38.19, -24.22, 9.50)
9:94487181		Q>R	B:532	(-44.70, -27.97, 6.67)
9:94487175		P>H	B:534	(-51.60, -28.13, 2.40)
9:94487172		N>S	B:535	(-51.56, -25.92, -0.87)
9:94487146	rs374811924	T>A	B:544	(-26.24, -36.55, 5.01)
9:94487134	rs35764413	P>S	B:548	(-25.85, -38.36, -3.37)
9:94487130		L>P	B:549	(-25.51, -34.94, -0.11)
9:94487123		M>I	B:551	(-33.12, -31.85, -0.59)
9:94487122	rs200008731	I>V	B:552	(-36.17, -36.41, -0.16)
9:94487112		Y>C	B:555	(-43.43, -34.88, -7.77)
9:94487109	rs545686056	C>S	B:556	(-47.03, -35.80, -8.17)
9:94487106	rs56099091	S>L	B:557	(-49.02, -39.00, -9.39)
9:94487101	rs117134265	G>S	B:559	(-48.65, -33.87, -12.78)
9:94487088		E>G	B:563	(-48.81, -31.38, -18.29)
9:94487089	rs186571882	E>K	B:563	(-48.81, -31.38, -18.29)
9:94487076	COSM1111029	M>T	B:567	(-54.35, -33.26, -21.66)
9:94487077	rs552717097	M>L	B:567	(-54.35, -33.26, -21.66)
9:94487073		R>H	B:568	(-58.13, -32.12, -19.54)
9:94487067	rs546802275 COSM241449	P>L	B:570	(-61.02, -26.89, -25.94)
9:94487064	rs376970201	H>R	B:571	(-58.54, -25.91, -28.76)
9:94487034	rs151303242	R>H	B:581	(-58.06, -42.21, -29.18)
9:94487035	COSM48758	R>C	B:581	(-58.06, -42.21, -29.18)
9:94487031	rs368499304 COSM3908821	T>M	B:582	(-57.78, -40.45, -25.74)
9:94487019		A>V	B:586	(-63.98, -33.19, -17.07)
9:94487020	rs142386294	A>T	B:586	(-63.98, -33.19, -17.07)
9:94487016		L>P	B:587	(-62.36, -29.57, -15.97)
9:94487012	rs201400446 COSM3659482	E>D	B:588	(-67.11, -29.18, -13.64)
9:94487011	rs148271834	P>S	B:589	(-66.80, -24.47, -13.54)
9:94487007		P>L	B:590	(-66.23, -25.45, -9.85)
9:94487008		P>S	B:590	(-66.23, -25.45, -9.85)
9:94486990		V>M	B:596	(-57.12, -20.48, -8.22)
9:94486983		Q>R	B:598	(-55.73, -25.05, -3.78)
9:94486977	rs143738026	A>V	B:600	(-53.67, -18.61, -2.97)
9:94486978		A>T	B:600	(-53.67, -18.61, -2.97)
9:94486974		A>V	B:601	(-53.11, -20.48, -0.03)
9:94486975		A>T	B:601	(-53.11, -20.48, -0.03)
9:94486956	COSM3659480	S>F	B:607	(-45.88, -14.71, 1.89)
9:94486953		S>N	B:608	(-46.20, -15.55, 5.65)
9:94486945	rs374748836	V>M	B:611	(-40.95, -17.24, 0.65)
9:94486942	rs148644518	V>L	B:612	(-39.76, -15.01, -2.97)
9:94486920		R>H	B:619	(-44.12, -23.81, -15.36)
9:94486917		N>S	B:620	(-43.89, -24.72, -11.03)
9:94486908		V>A	B:623	(-51.93, -32.48, -9.65)
9:94486903		D>N	B:625	(-55.12, -37.48, -5.23)
9:94486898		K>N	B:626	(-59.63, -35.25, -3.77)
9:94486891	rs148844963	V>M	B:629	(-52.75, -28.02, -5.74)
9:94486863		R>Q	B:638	(-38.76, -29.45, -16.50)
9:94486857		V>A	B:640	(-40.05, -29.32, -21.40)
9:94486858		V>L	B:640	(-40.05, -29.32, -21.40)
9:94486851		A>V	B:642	(-37.50, -23.57, -22.57)
9:94486846	rs55798732	D>N	B:644	(-41.77, -20.80, -20.59)
9:94486836	rs369059394	K>R	B:647	(-30.66, -15.96, -21.92)
9:94486821	rs541919750	S>L	B:652	(-29.96, -16.40, -16.08)
9:94486812		P>L	B:655	(-39.86, -16.11, -16.08)
9:94486813		P>S	B:655	(-39.86, -16.11, -16.08)
9:94486806	rs529829552	R>H	B:657	(-44.12, -14.96, -21.88)
9:94486807	COSM1111027	R>C	B:657	(-44.12, -14.96, -21.88)
9:94486782		M>T	B:665	(-36.83, -2.43, -15.12)
9:94486777	COSM1165432	G>S	B:667	(-34.39, -8.39, -11.61)
9:94486773	COSM1173525	K>T	B:668	(-35.92, -7.00, -8.41)
9:94486770	rs200159827	F>S	B:669	(-37.75, -11.82, -8.79)
9:94486768		S>P	B:670	(-41.29, -9.66, -4.94)
9:94486714	rs199506849	Y>D	B:688	(-58.83, -24.60, -20.77)
9:94486711		G>S	B:689	(-52.60, -23.49, -21.01)
9:94486696	rs142386992	C>R	B:694	(-49.43, -16.77, -27.79)
9:94486693	rs34431454	G>R	B:695	(-46.97, -15.55, -30.90)
9:94486687		S>P	B:697	(-41.49, -12.82, -29.38)
9:94486677		D>G	B:700	(-42.17, -8.57, -29.03)
9:94486667	rs200805854	E>D	B:703	(-41.06, -4.48, -26.49)
9:94486664		M>I	B:704	(-46.21, -5.97, -24.83)
9:94486666		M>V	B:704	(-46.21, -5.97, -24.83)
9:94486659	rs369717474 COSM1187759	R>Q	B:706	(-40.49, -2.33, -21.41)
9:94486660		R>W	B:706	(-40.49, -2.33, -21.41)
9:94486653		R>Q	B:708	(-48.63, -1.82, -20.13)
9:94486654		R>W	B:708	(-48.63, -1.82, -20.13)
9:94486642	rs374945194 COSM1196259	P>S	B:712	(-56.11, -10.91, -22.93)
9:94486638		C>Y	B:713	(-60.33, -11.77, -21.46)
9:94486633	rs201994918	D>N	B:715	(-62.76, -17.30, -23.33)
9:94486626		C>S	B:717	(-63.68, -15.53, -18.30)
9:94486624		P>S	B:718	(-65.36, -15.25, -15.42)
9:94486600		I>V	B:726	(-56.81, -6.07, -13.81)
9:94486585	COSM284668	E>K	B:731	(-48.38, 1.04, -12.45)
9:94486573	COSM1463539	R>W	B:735	(-51.73, 1.01, -5.33)
9:94486566		P>L	B:737	(-54.06, -7.83, -4.36)
9:94486563	COSM3670071	R>H	B:738	(-51.19, -8.19, -0.86)
9:94486559		F>L	B:739	(-51.20, -13.86, -2.19)
9:94486561		F>L	B:739	(-51.20, -13.86, -2.19)
9:94486555	COSM3659472	D>Y	B:741	(-57.28, -10.33, 0.65)
9:94486548		H>R	B:743	(-57.81, -17.86, 0.08)
9:94486546		S>C	B:744	(-60.69, -14.75, 1.11)
9:94486542		R>Q	B:745	(-61.54, -11.51, -3.27)
9:94486543		R>W	B:745	(-61.54, -11.51, -3.27)
9:94486536	rs201155263	R>Q	B:747	(-63.29, -19.33, -0.33)
9:94486525	rs73504470	N>D	B:751	(-68.52, -21.37, -0.48)
9:94486521		L>P	B:752	(-71.42, -19.75, -3.81)

4GT4.B | ROR2.

4GT4.B | ROR2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:94487188	COSM1663950	R>W	B:530	(-38.19, -24.22, 9.50)
9:94487151	COSM1463542	V>A	B:542	(-32.13, -35.36, 4.48)
9:94487106	COSM131811	S>L	B:557	(-49.02, -39.00, -9.39)
9:94486962	COSM3221806	Y>S	B:605	(-47.15, -21.13, 4.55)
9:94486933	COSM1756265	D>N	B:615	(-41.06, -19.61, -11.50)
9:94486921	COSM4958336	R>S	B:619	(-44.12, -23.81, -15.36)
9:94486807	COSM1111027	R>C	B:657	(-44.12, -14.96, -21.88)
9:94486762	COSM176568	D>N	B:672	(-45.45, -7.31, -5.02)
9:94486740	COSM3382601	G>D	B:679	(-52.46, -13.58, -12.61)
9:94486642	COSM1196259	P>S	B:712	(-56.11, -10.91, -22.93)
9:94486585	COSM284668	E>K	B:731	(-48.38, 1.04, -12.45)
9:94486573	COSM1463539	R>W	B:735	(-51.73, 1.01, -5.33)
9:94486527	COSM1581607	G>D	B:750	(-67.13, -21.05, -3.85)