General Structure Information
| PDB ID | 3qx3 |
| HGNC Gene Label(s) | TOP2B |
| Structure Name | human topoisomerase iibeta in complex with dna and etoposide |
| Resolution | 2.16Å |
| Reference | AUTH C.C.WU,T.K.LI,L.FARH,L.Y.LIN,T.S.LIN,Y.J.YU,T.J.YEN,AUTH 2 C.W.CHIANG,N.L.CHANTITL STRUCTURAL BASIS OF TYPE II TOPOISOMERASE INHIBITION BY THETITL 2 ANTICANCER DRUG ETOPOSIDEREF SCIENCE V. 333 459 2011REFN ISSN 0036-8075PMID 21778401DOI 10.1126/SCIENCE.1204117 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 671 |
| Number Of SNVs | 65 |
| Number Of Permutations | 56026 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.28 |
| p-value | 0.078 |
COSMIC
| Number Of Residues | 671 |
| Number Of SNVs | 5 |
| Number Of Permutations | 879 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.2 |
| p-value | 0.879 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.212 |
| p-value | 0.535 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
