General Structure Information
| PDB ID | 3g45 |
| HGNC Gene Label(s) | PDE4B |
| Structure Name | crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 |
| Resolution | 2.63Å |
| Reference | AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 371 |
| Number Of SNVs | 59 |
| Number Of Permutations | 9964 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.083 |
| p-value | 0.266 |
COSMIC
| Number Of Residues | 371 |
| Number Of SNVs | 9 |
| Number Of Permutations | 1712 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.056 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.026 |
| p-value | 0.966 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
