General Structure Information
| PDB ID | 3qxm |
| HGNC Gene Label(s) | GRIK2 |
| Structure Name | crystal structure of human gluk2 ligand-binding core in complex with novel marine-derived toxins, neodysiherbaine a |
| Resolution | 1.65Å |
| Reference | AUTH M.UNNO,M.SHINOHARA,K.TAKAYAMA,H.TANAKA,K.TERUYA,K.DOH-URA,AUTH 2 R.SAKAI,M.SASAKI,M.IKEDA-SAITOTITL BINDING AND SELECTIVITY OF THE MARINE TOXIN NEODYSIHERBAINETITL 2 A AND ITS SYNTHETIC ANALOGUES TO GLUK1 AND GLUK2 KAINATETITL 3 RECEPTORS.REF J.MOL.BIOL. V. 413 667 2011REFN ISSN 0022-2836PMID 21893069DOI 10.1016/J.JMB.2011.08.043 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 256 |
| Number Of SNVs | 34 |
| Number Of Permutations | 4886 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.132 |
| p-value | 0.398 |
COSMIC
| Number Of Residues | 256 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3327 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.048 |
| p-value | 0.345 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.061 |
| p-value | 0.402 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
