General Structure Information
| PDB ID | 2ymk |
| HGNC Gene Label(s) | DCD |
| Structure Name | crystal structure of the hexameric anti-microbial peptide channel dermcidin |
| Resolution | 2.49Å |
| Reference | AUTH C.SONG,C.WEICHBRODT,E.S.SALNIKOV,M.DYNOWSKI,B.O.FORSBERG,AUTH 2 B.BECHINGER,C.STEINEM,B.L.DE GROOT,U.ZACHARIAE,K.ZETHTITL CRYSTAL STRUCTURE AND FUNCTIONAL MECHANISM OF A HUMANTITL 2 ANTIMICROBIAL MEMBRANE CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 4586 2013REFN ISSN 0027-8424PMID 23426625DOI 10.1073/PNAS.1214739110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 47 |
| Number Of SNVs | 12 |
| Number Of Permutations | 8312 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.606 |
| p-value | 0.038 |
COSMIC
| Number Of Residues | 47 |
| Number Of SNVs | 3 |
| Number Of Permutations | 56 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.333 |
| p-value | 0.135 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.333 |
| p-value | 0.693 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
