3UB2.A | TIRAP

General Structure Information

PDB ID	3ub2
HGNC Gene Label(s)	TIRAP
Structure Name	tir domain of mal/tirap
Resolution	2.4Å
Reference	AUTH Z.LIN,J.LU,W.ZHOU,Y.SHENTITL STRUCTURAL INSIGHTS INTO TIR DOMAIN SPECIFICITY OF THETITL 2 BRIDGING ADAPTOR MAL IN TLR4 SIGNALINGREF PLOS ONE V. 7 34202 2012REFN ESSN 1932-6203PMID 22485159DOI 10.1371/JOURNAL.PONE.0034202

Variant Set Distributions

ExAC Variants

Number Of Residues	125
Number Of SNVs	45
Number Of Permutations	12364
Optimal Distance Threshold	8.0
K Statistic	0.085
p-value	0.387

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:126162543		S>N	A:80	(-18.58, 4.31, -8.09)
11:126162545	rs138228187	R>C	A:81	(-24.49, 3.95, -9.53)
11:126162546		R>H	A:81	(-24.49, 3.95, -9.53)
11:126162554		K>E	A:84	(-19.71, -2.30, -11.63)
11:126162566		V>I	A:88	(-29.00, -5.74, -11.08)
11:126162572		V>M	A:90	(-30.90, -12.24, -12.72)
11:126162587		E>K	A:95	(-36.38, -24.37, -14.96)
11:126162615		V>D	A:104	(-35.09, -7.73, -15.38)
11:126162618	COSM355839 COSM355838	S>Y	A:105	(-38.90, -5.82, -16.09)
11:126162696		S>F	A:131	(-31.09, -4.66, -15.42)
11:126162698	rs147530219	E>K	A:132	(-27.97, -8.11, -17.09)
11:126162704	rs74937157	C>R	A:134	(-26.39, -13.04, -15.05)
11:126162706		C>W	A:134	(-26.39, -13.04, -15.05)
11:126162731	rs200632029	R>W	A:143	(-24.94, -11.79, -8.98)
11:126162741		L>R	A:146	(-34.04, -17.17, -9.09)
11:126162743		I>V	A:147	(-33.00, -19.88, -5.00)
11:126162747	rs372803124	T>M	A:148	(-35.46, -22.39, -8.05)
11:126162750		P>L	A:149	(-36.52, -25.94, -7.77)
11:126162755	rs574384452	F>V	A:151	(-30.31, -22.45, -8.42)
11:126162761		Q>E	A:153	(-32.06, -29.94, -8.98)
11:126162764	rs377193452	D>Y	A:154	(-27.67, -26.89, -11.40)
11:126162774		C>Y	A:157	(-26.37, -23.05, -9.98)
11:126162787		M>I	A:161	(-24.95, -19.85, -4.30)
11:126162795	rs543271785	A>D	A:164	(-21.72, -15.12, -4.93)
11:126162801	rs559677379	T>I	A:166	(-17.15, -16.03, -2.04)
11:126162803		E>K	A:167	(-16.23, -11.54, -2.16)
11:126162806		A>T	A:168	(-20.39, -11.13, -0.77)
11:126162810		P>L	A:169	(-23.17, -10.54, 1.06)
11:126162813		G>E	A:170	(-21.28, -10.22, 4.79)
11:126162828		T>I	A:175	(-25.82, -11.19, -2.81)
11:126162832	rs368918609	I>M	A:176	(-30.30, -10.35, -3.35)
11:126162843	rs8177374	S>L	A:180	(-39.11, -19.05, -5.97)
11:126162848		L>F	A:182	(-38.96, -23.57, -2.99)
11:126162855		R>K	A:184	(-40.67, -21.48, 4.89)
11:126162875		L>F	A:191	(-30.76, -18.98, 4.04)
11:126162879		R>Q	A:192	(-31.62, -20.24, 11.18)
11:126162884		M>V	A:194	(-28.21, -15.76, 5.21)
11:126162885	COSM1676574 COSM1676573	M>T	A:194	(-28.21, -15.76, 5.21)
11:126162891	rs532728808	Y>C	A:196	(-34.48, -15.05, 3.15)
11:126162893	rs7932976	V>I	A:197	(-36.43, -12.38, -0.54)
11:126162903		R>T	A:200	(-44.26, -17.56, -0.06)
11:126162905	rs563269513	G>R	A:201	(-44.35, -11.75, -1.09)
11:126162908		P>S	A:202	(-44.72, -8.47, -1.80)
11:126162924	rs199561634	R>H	A:207	(-42.74, -4.54, -3.33)
11:126162927		Q>P	A:208	(-37.83, -7.22, -0.10)
11:126162945	rs148618551	M>T	A:214	(-33.02, 1.04, -4.44)
11:126162948	rs185114125	R>H	A:215	(-31.83, -1.16, 0.89)
11:126162963		Q>L	A:220	(-22.77, 3.70, -4.32)

3UB2.A | TIRAP.

3UB2.A | TIRAP

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:126162545	COSM924677	R>C	A:81	(-24.49, 3.95, -9.53)
11:126162843	COSM4986364	S>L	A:180	(-39.11, -19.05, -5.97)
11:126162948	COSM72984	R>H	A:215	(-31.83, -1.16, 0.89)