General Structure Information
| PDB ID | 1so2 |
| HGNC Gene Label(s) | PDE3B |
| Structure Name | catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor |
| Resolution | 2.4Å |
| Reference | AUTH G.SCAPIN,S.B.PATEL,C.CHUNG,J.P.VARNERIN,AUTH 2 S.D.EDMONDSON,A.MASTRACCHIO,E.R.PARMEE,S.B.SINGH,AUTH 3 J.W.BECKER,L.H.VAN DER PLOEG,M.R.TOTATITL CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 3B:TITL 2 ATOMIC BASIS FOR SUBSTRATE AND INHIBITORTITL 3 SPECIFICITYREF BIOCHEMISTRY V. 43 6091 2004REFN ISSN 0006-2960PMID 15147193DOI 10.1021/BI049868I |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 365 |
| Number Of SNVs | 86 |
| Number Of Permutations | 44564 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.067 |
| p-value | 0.775 |
COSMIC
| Number Of Residues | 365 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1043 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.3 |
| p-value | 0.232 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 86 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.32 |
| p-value | 0.208 |