1FVR.A | TEK – ASTRID

1FVR.A | TEK

General Structure Information

PDB ID	1fvr
HGNC Gene Label(s)	TEK
Structure Name	tie2 kinase domain
Resolution	2.2Å
Reference	AUTH L.M.SHEWCHUK,A.M.HASSELL,B.ELLIS,W.D.HOLMES,AUTH 2 R.DAVIS,E.L.HORNE,S.H.KADWELL,D.D.MCKEE,J.T.MOORETITL STRUCTURE OF THE TIE2 RTK DOMAIN: SELF-INHIBITIONTITL 2 BY THE NUCLEOTIDE BINDING LOOP, ACTIVATION LOOP,TITL 3 AND C-TERMINAL TAIL.REF STRUCTURE FOLD.DES. V. 8 1105 2000REFN ISSN 0969-2126PMID 11080633DOI 10.1016/S0969-2126(00)00516-5

Variant Set Distributions

ExAC Variants

Number Of Residues	299
Number Of SNVs	57
Number Of Permutations	10190
Optimal Distance Threshold	7.0
K Statistic	0.03
p-value	0.818

ClinVar

Number Of Residues	299
Number Of SNVs	3
Number Of Permutations	176
Optimal Distance Threshold	20.0
K Statistic	0.0
p-value	0.608

COSMIC

Number Of Residues	299
Number Of SNVs	8
Number Of Permutations	4196
Optimal Distance Threshold	13.0
K Statistic	0.036
p-value	0.378

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs	57
Number Of ClinVar SNVs	3
Optimal Distance Threshold	20.0
K Statistic	-0.294
p-value	0.054

Cosmic vs. ExAC

Number Of ExAC SNVs	57
Number Of COSMIC SNVs	10
Optimal Distance Threshold	22.0
K Statistic	-0.105
p-value	0.566

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:27206658	rs546234201	I>V	A:815	(-13.73, -11.10, 12.53)
9:27206659		I>N	A:815	(-13.73, -11.10, 12.53)
9:27206698	rs532313466	D>G	A:828	(-4.71, -4.32, 32.37)
9:27206703		I>V	A:830	(-1.67, -8.08, 28.96)
9:27206737		A>V	A:841	(-11.21, -7.58, 29.02)
9:27206739	rs147231791	R>C	A:842	(-15.37, -9.05, 31.54)
9:27206740	rs200750146	R>H	A:842	(-15.37, -9.05, 31.54)
9:27206761	rs376225163	R>Q	A:849	(-20.18, -9.48, 30.44)
9:27206782		R>T	A:856	(-5.63, -0.44, 19.10)
9:27209122		Y>C	A:860	(-3.93, 2.96, 8.62)
9:27209152		A>V	A:870	(-5.60, -6.87, 5.00)
9:27209199		I>V	A:886	(-5.51, -18.12, 20.73)
9:27209203		N>S	A:887	(-9.78, -19.13, 19.63)
9:27209227		R>Q	A:895	(-12.07, 6.95, 17.39)
9:27212724		I>M	A:902	(-8.35, -12.74, 21.87)
9:27212783	COSM3656754 COSM3656753	T>M	A:922	(9.92, -20.77, 44.57)
9:27212791	rs138463877	A>T	A:925	(10.09, -26.45, 51.82)
9:27212824		L>V	A:936	(4.42, -29.12, 36.80)
9:27212845	rs143080429	H>Y	A:943	(-0.98, -33.80, 28.66)
9:27212851		A>T	A:945	(3.40, -31.21, 24.25)
9:27212854		A>T	A:946	(0.34, -32.56, 23.15)
9:27212861	rs559941890	V>G	A:948	(1.56, -27.64, 20.94)
9:27212864		A>V	A:949	(1.03, -30.93, 18.54)
9:27212867	rs376285577	R>Q	A:950	(-3.66, -31.73, 20.02)
9:27213519		V>A	A:972	(-1.47, -21.49, 30.08)
9:27213522		G>A	A:973	(-5.33, -21.65, 29.91)
9:27213524		E>K	A:974	(-9.90, -21.62, 30.40)
9:27213545	COSM241867	A>T	A:981	(0.13, -17.89, 19.37)
9:27217699		V>A	A:1002	(18.76, -17.97, 16.40)
9:27217701	COSM2154292 COSM2154291	R>C	A:1003	(19.17, -19.80, 21.02)
9:27217702	COSM3788251 COSM3788250	R>H	A:1003	(19.17, -19.80, 21.02)
9:27217715	rs368457184	I>M	A:1007	(19.97, -25.56, 9.46)
9:27217743		T>P	A:1017	(5.70, -27.13, 8.23)
9:27218783		Y>F	A:1024	(7.40, -29.38, 19.15)
9:27220064		G>R	A:1041	(26.28, -19.97, 26.38)
9:27220071		T>S	A:1043	(27.00, -17.37, 20.87)
9:27220079	COSM1461888 COSM1461887	E>Q	A:1046	(28.96, -20.40, 18.99)
9:27220086		Y>C	A:1048	(24.06, -18.71, 12.39)
9:27220088		E>K	A:1049	(30.30, -22.47, 13.40)
9:27220102	rs201502264	Q>H	A:1053	(29.47, -28.57, 12.13)
9:27220139		E>K	A:1066	(10.88, -42.35, 23.86)
9:27220142		V>M	A:1067	(11.58, -37.56, 25.03)
9:27228205		Y>N	A:1068	(17.40, -36.36, 23.05)
9:27228211		L>I	A:1070	(10.62, -36.94, 19.65)
9:27228214	rs550879968	M>V	A:1071	(13.95, -33.78, 21.08)
9:27228228		W>C	A:1075	(16.43, -31.12, 16.98)
9:27228229	COSM1108005 COSM375912	R>W	A:1076	(15.71, -36.14, 11.52)
9:27228230	rs536255448	R>Q	A:1076	(15.71, -36.14, 11.52)
9:27228242		Y>S	A:1080	(13.44, -34.61, 3.14)
9:27228266		I>T	A:1088	(4.94, -35.47, 17.18)
9:27228267	rs548612956	I>M	A:1088	(4.94, -35.47, 17.18)
9:27228271		V>L	A:1090	(1.18, -40.78, 18.03)
9:27228287		M>K	A:1095	(4.99, -41.46, 26.07)
9:27228299		R>Q	A:1099	(2.93, -45.49, 34.17)
9:27229156		T>A	A:1101	(8.23, -41.35, 34.53)
9:27229172	COSM43022 COSM2150485	T>M	A:1106	(11.57, -36.85, 41.59)
9:27229178		Y>F	A:1108	(14.61, -39.58, 43.09)
9:27229182	COSM95321	E>D	A:1109	(20.31, -39.32, 45.72)
9:27229184		K>R	A:1110	(21.87, -34.99, 41.61)
9:27229189		T>A	A:1112	(20.14, -30.10, 37.70)
9:27229207		C>R	A:1118	(18.85, -13.36, 30.99)
9:27229214		A>V	A:1120	(19.79, -14.21, 25.70)

1FVR.A | TEK.

1FVR.A | TEK

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:27206760	rs80338908	R>W	A:849	(-20.18, -9.48, 30.44)
9:27212708	rs80338909	Y>S	A:897	(-7.58, 2.35, 15.62)
9:27212762	rs387906745	R>H	A:915	(11.44, -19.89, 33.57)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:27206671	COSM3906733	L>P	A:819	(-18.23, -7.17, 19.52)
9:27206739	COSM3413574	R>C	A:842	(-15.37, -9.05, 31.54)
9:27206760	COSM4588754	R>W	A:849	(-20.18, -9.48, 30.44)
9:27212761	COSM1107999	R>C	A:915	(11.44, -19.89, 33.57)
9:27212860	COSM1228893	V>M	A:948	(1.56, -27.64, 20.94)
9:27213572	COSM158730	E>K	A:990	(8.59, -21.70, 1.38)
9:27217701	COSM2154291	R>C	A:1003	(19.17, -19.80, 21.02)
9:27228229	COSM1108005	R>W	A:1076	(15.71, -36.14, 11.52)
9:27228274	COSM2771614	S>P	A:1091	(4.65, -40.40, 20.01)
9:27229172	COSM43022	T>M	A:1106	(11.57, -36.85, 41.59)
9:27229187	COSM1674432	F>C	A:1111	(16.85, -32.05, 39.68)