General Structure Information
| PDB ID | 3bpr |
| HGNC Gene Label(s) | MERTK |
| Structure Name | crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 |
| Resolution | 2.8Å |
| Reference | AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 261 |
| Number Of SNVs | 68 |
| Number Of Permutations | 12007 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.04 |
| p-value | 0.828 |
COSMIC
| Number Of Residues | 261 |
| Number Of SNVs | 4 |
| Number Of Permutations | 297 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 0.818 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.078 |
| p-value | 0.946 |