General Structure Information
| PDB ID | 2qyn |
| HGNC Gene Label(s) | PDE4D |
| Structure Name | crystal structure of pde4d2 in complex with inhibitor npv |
| Resolution | 1.57Å |
| Reference | AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 326 |
| Number Of SNVs | 34 |
| Number Of Permutations | 16586 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.13 |
| p-value | 0.603 |
ClinVar
| Number Of Residues | 326 |
| Number Of SNVs | 3 |
| Number Of Permutations | 215 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.0 |
| p-value | 0.756 |
COSMIC
| Number Of Residues | 326 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.595 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.219 |
| p-value | 0.07 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.52 |
| p-value | 0.684 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
