4OAV.B | RNASEL

General Structure Information

PDB ID	4oav
HGNC Gene Label(s)	RNASEL
Structure Name	complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate.
Resolution	2.1Å
Reference	AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845

Variant Set Distributions

ExAC Variants

Number Of Residues	673
Number Of SNVs	189
Number Of Permutations	53050
Optimal Distance Threshold	8.0
K Statistic	0.016
p-value	0.486

COSMIC

Number Of Residues	673
Number Of SNVs	8
Number Of Permutations	5256
Optimal Distance Threshold	5.0
K Statistic	0.036
p-value	0.182

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	189
Number Of COSMIC SNVs	7
Optimal Distance Threshold	5.0
K Statistic	0.045
p-value	0.306

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:182555847		A>G	B:32	(38.80, 28.58, 105.52)
1:182555842		Q>E	B:34	(34.23, 24.86, 104.52)
1:182555838		N>S	B:35	(38.16, 23.95, 107.68)
1:182555839		N>D	B:35	(38.16, 23.95, 107.68)
1:182555836		E>K	B:36	(35.82, 26.22, 111.84)
1:182555825		D>E	B:39	(43.90, 32.76, 112.04)
1:182555823		L>P	B:40	(43.41, 31.37, 106.72)
1:182555803		G>S	B:47	(44.66, 40.31, 101.25)
1:182555797		A>T	B:49	(39.65, 38.40, 99.24)
1:182555793	rs145581875	N>S	B:50	(35.65, 38.17, 96.83)
1:182555767	rs151296858	G>S	B:59	(25.85, 30.17, 95.45)
1:182555758	rs114166108	P>S	B:62	(31.85, 32.97, 102.23)
1:182555749		N>D	B:65	(29.91, 28.27, 104.29)
1:182555746		A>T	B:66	(29.71, 30.67, 108.36)
1:182555721		I>T	B:74	(33.86, 33.38, 110.93)
1:182555722		I>V	B:74	(33.86, 33.38, 110.93)
1:182555709	rs199717324 COSM99005	L>P	B:78	(32.90, 37.65, 106.57)
1:182555704	rs146324223	R>G	B:80	(33.23, 44.17, 111.33)
1:182555688		P>L	B:85	(24.02, 40.86, 104.70)
1:182555689		P>S	B:85	(24.02, 40.86, 104.70)
1:182555686		V>I	B:86	(20.87, 39.91, 102.33)
1:182555670	rs367543931	N>S	B:91	(17.87, 28.05, 97.26)
1:182555661	rs141809307	T>M	B:94	(18.95, 34.02, 103.42)
1:182555655		F>S	B:96	(17.28, 34.94, 108.98)
1:182555652		I>N	B:97	(16.88, 31.10, 106.18)
1:182555647	COSM900686	A>S	B:99	(20.51, 30.47, 111.10)
1:182555640	rs115634589	I>T	B:101	(19.10, 25.36, 109.27)
1:182555635		G>R	B:103	(20.19, 27.28, 115.64)
1:182555629	COSM212984	V>M	B:105	(19.47, 32.93, 118.52)
1:182555613		L>P	B:110	(23.31, 39.67, 113.39)
1:182555598		G>E	B:115	(17.54, 43.33, 107.04)
1:182555592		D>V	B:117	(11.75, 39.86, 107.04)
1:182555586		N>T	B:119	(8.08, 36.19, 107.57)
1:182555577	rs201382126	D>G	B:122	(13.25, 29.67, 99.86)
1:182555559	COSM3479916	A>D	B:128	(13.15, 30.37, 109.32)
1:182555531	rs542521353	K>N	B:137	(16.98, 23.68, 115.93)
1:182555530		V>F	B:138	(13.60, 24.70, 120.34)
1:182555524		A>S	B:140	(15.04, 29.24, 117.09)
1:182555484		L>W	B:153	(3.07, 30.68, 106.43)
1:182555482	rs144213776	R>G	B:154	(-0.09, 26.79, 102.66)
1:182555473		T>S	B:157	(6.42, 26.94, 95.03)
1:182555457		E>V	B:162	(2.06, 25.06, 92.54)
1:182555454		R>P	B:163	(2.17, 23.16, 86.79)
1:182555443		G>R	B:167	(3.39, 22.69, 98.24)
1:182555419	rs374109517 COSM2097088	A>S	B:175	(7.72, 18.46, 112.75)
1:182555416		A>T	B:176	(5.85, 15.61, 111.93)
1:182555409		K>R	B:178	(11.79, 15.38, 109.81)
1:182555401	COSM208821	V>I	B:181	(7.97, 15.64, 119.92)
1:182555398		E>Q	B:182	(9.31, 18.90, 122.58)
1:182555395		V>F	B:183	(8.75, 21.41, 117.84)
1:182555391	rs182539049	L>S	B:184	(4.47, 19.06, 117.38)
1:182555369		M>I	B:191	(3.56, 28.88, 118.67)
1:182555371		M>L	B:191	(3.56, 28.88, 118.67)
1:182555367		G>A	B:192	(-1.10, 28.28, 116.98)
1:182555361		D>V	B:194	(-3.92, 24.68, 111.78)
1:182555359	rs146781980	V>I	B:195	(-3.97, 20.54, 113.43)
1:182555353		A>P	B:197	(-3.58, 22.05, 107.55)
1:182555346		D>G	B:199	(-0.28, 19.74, 101.41)
1:182555337		G>D	B:202	(-3.72, 17.07, 101.07)
1:182555338		G>C	B:202	(-3.72, 17.07, 101.07)
1:182555319		H>R	B:208	(3.36, 15.08, 106.31)
1:182555316	rs374914079	A>G	B:209	(3.78, 11.59, 110.50)
1:182555298	rs369225651	D>G	B:215	(9.25, 5.12, 112.66)
1:182555299	rs373482948	D>N	B:215	(9.25, 5.12, 112.66)
1:182555290	COSM900684	V>L	B:218	(5.22, 7.91, 115.05)
1:182555281	rs149498082	I>V	B:221	(3.88, 12.85, 116.80)
1:182555277		T>M	B:222	(-0.03, 10.23, 116.29)
1:182555271	rs138685180	L>P	B:224	(0.42, 15.15, 120.43)
1:182555229		R>K	B:238	(0.22, 5.24, 96.08)
1:182555227	rs376574386	G>R	B:239	(-5.21, 6.93, 99.13)
1:182555217		P>R	B:242	(-4.25, 7.63, 108.33)
1:182555218		P>T	B:242	(-4.25, 7.63, 108.33)
1:182555215		L>M	B:243	(-5.92, 3.04, 109.41)
1:182555212		I>V	B:244	(-4.08, 2.31, 105.21)
1:182555179		V>M	B:255	(-3.87, 0.63, 114.61)
1:182555169	rs143565946	L>H	B:258	(-5.90, 5.67, 114.60)
1:182555148		E>A	B:265	(-14.62, 6.05, 107.69)
1:182555146		I>V	B:266	(-12.82, 1.01, 109.21)
1:182555115	rs145415894	A>V	B:276	(-6.93, -1.95, 106.16)
1:182555107		L>F	B:279	(-3.47, -4.14, 103.31)
1:182555089	rs140715742	L>M	B:285	(-0.53, -7.99, 110.11)
1:182555077	rs35553278	A>P	B:289	(-6.84, -7.97, 111.65)
1:182555067		L>P	B:292	(-9.45, -3.89, 111.92)
1:182555065		C>G	B:293	(-12.64, -7.34, 112.80)
1:182555062	rs143544690	K>E	B:294	(-12.55, -7.28, 117.67)
1:182555058		R>H	B:295	(-13.43, -1.02, 116.66)
1:182555053		A>T	B:297	(-14.42, -4.14, 109.66)
1:182555046		T>R	B:299	(-15.37, -8.93, 105.82)
1:182555032		L>V	B:304	(-10.03, -11.56, 103.31)
1:182555019	rs554935584	A>V	B:308	(-5.17, -16.64, 105.15)
1:182555020		A>T	B:308	(-5.17, -16.64, 105.15)
1:182555013		R>Q	B:310	(-3.02, -18.01, 99.53)
1:182554965		K>R	B:326	(-16.99, -13.57, 101.00)
1:182554966	rs370880759	K>E	B:326	(-16.99, -13.57, 101.00)
1:182554932		K>M	B:337	(-5.78, -14.18, 74.30)
1:182554913		W>C	B:343	(6.47, -20.09, 74.59)
1:182554906		A>T	B:346	(1.58, -21.28, 79.85)
1:182554898	rs368121242	K>N	B:348	(-3.87, -18.81, 78.77)
1:182554896		D>V	B:349	(-1.85, -21.45, 83.13)
1:182554883	rs557176736	I>M	B:353	(-1.44, -18.66, 88.81)
1:182554878		R>L	B:355	(3.28, -16.43, 92.25)
1:182554879	rs148464936	R>C	B:355	(3.28, -16.43, 92.25)
1:182554873	rs375149435	M>V	B:357	(3.81, -9.36, 92.29)
1:182554864		K>E	B:360	(7.02, -3.49, 87.55)
1:182554843		E>Q	B:367	(10.19, -27.31, 84.52)
1:182554810		G>S	B:378	(16.79, -19.39, 83.75)
1:182554797	rs546259318	G>E	B:382	(6.32, -13.41, 82.06)
1:182554792		Y>H	B:384	(8.23, -5.51, 83.67)
1:182554783		Q>E	B:387	(3.21, -6.53, 78.96)
1:182554778		E>D	B:388	(3.82, -11.64, 76.72)
1:182554766	rs374634843	K>N	B:392	(18.36, -14.16, 81.74)
1:182554764		T>M	B:393	(17.80, -15.92, 86.07)
1:182554752		G>D	B:397	(26.74, -10.00, 91.23)
1:182554743	rs137993708	R>P	B:400	(27.27, -14.84, 82.95)
1:182554744	rs377048179 COSM1500402	R>C	B:400	(27.27, -14.84, 82.95)
1:182554734	rs141194514	R>Q	B:403	(29.22, -9.59, 81.45)
1:182554735		R>G	B:403	(29.22, -9.59, 81.45)
1:182554728		V>A	B:405	(22.34, -5.18, 82.87)
1:182554725	rs145787003	S>F	B:406	(25.34, -3.01, 81.26)
1:182554722	rs376651440	C>Y	B:407	(24.26, -3.96, 77.21)
1:182554717	rs563565046 COSM900679	Q>K	B:409	(21.08, -0.44, 81.33)
1:182554711	rs551605499	S>G	B:411	(20.56, -1.05, 73.97)
1:182554691		L>F	B:417	(18.81, -5.59, 70.00)
1:182554681		Y>H	B:421	(10.05, -5.04, 78.17)
1:182554673		S>R	B:423	(15.22, -5.04, 86.12)
1:182554657		H>Y	B:429	(17.91, -13.63, 93.65)
1:182554636		L>F	B:436	(8.47, -13.72, 74.45)
1:182554557	rs486907	R>Q	B:462	(18.57, -12.54, 50.75)
1:182554553		N>K	B:463	(15.63, -11.35, 55.76)
1:182554540		I>V	B:468	(21.86, -10.18, 62.55)
1:182554521		E>G	B:474	(22.68, -0.76, 65.95)
1:182554522		E>K	B:474	(22.68, -0.76, 65.95)
1:182554514		H>Q	B:476	(29.99, -3.15, 67.40)
1:182554506		C>Y	B:479	(25.89, 0.62, 72.05)
1:182554493	rs190359946	H>Q	B:483	(27.44, -10.66, 71.62)
1:182554489	COSM900675	D>N	B:485	(27.93, -15.67, 72.15)
1:182554473	rs557182938	N>S	B:490	(22.08, -16.07, 70.97)
1:182554465		I>V	B:493	(12.76, -15.89, 65.44)
1:182553299	rs530895130	S>P	B:495	(5.59, -14.09, 65.31)
1:182553287		A>T	B:499	(15.24, -11.23, 63.88)
1:182553278		A>T	B:502	(20.45, -11.99, 72.22)
1:182553266	rs533485839	K>E	B:506	(29.80, -14.06, 77.27)
1:182551393		D>N	B:523	(31.57, -15.49, 65.08)
1:182551389		L>P	B:524	(28.74, -12.52, 61.40)
1:182551383	rs370214447	R>Q	B:526	(32.54, -18.82, 61.16)
1:182551384	rs371856235	R>W	B:526	(32.54, -18.82, 61.16)
1:182551371		Y>C	B:530	(23.85, -22.17, 60.67)
1:182551362		K>R	B:533	(24.71, -24.86, 54.01)
1:182551353	rs371715795	S>N	B:536	(23.51, -28.47, 57.54)
1:182551350		I>T	B:537	(26.94, -27.16, 58.83)
1:182551351	rs146365994	I>V	B:537	(26.94, -27.16, 58.83)
1:182551344	COSM463523	F>S	B:539	(28.26, -21.91, 64.78)
1:182551337	rs627928	D>E	B:541	(31.66, -27.86, 63.18)
1:182551336		L>V	B:542	(31.45, -23.70, 61.29)
1:182551329	rs141087868	A>D	B:544	(36.59, -25.59, 64.42)
1:182551282		K>E	B:560	(33.48, -17.52, 48.47)
1:182551269		H>P	B:564	(37.42, -12.79, 52.15)
1:182551266	rs143649586	R>H	B:565	(34.43, -8.18, 51.29)
1:182551267	rs200397730 COSM3479911	R>C	B:565	(34.43, -8.18, 51.29)
1:182551254		P>H	B:569	(38.42, -6.32, 57.37)
1:182551251		G>E	B:570	(39.86, -3.03, 56.53)
1:182551245		H>P	B:572	(37.92, 1.81, 56.07)
1:182551243	rs372951844	V>M	B:573	(36.59, -2.03, 60.46)
1:182551233		C>Y	B:576	(32.06, -3.34, 57.40)
1:182551234		C>S	B:576	(32.06, -3.34, 57.40)
1:182551225		D>H	B:579	(29.90, -0.96, 53.25)
1:182551192	rs558307922	E>K	B:590	(15.05, -9.11, 39.28)
1:182551188	rs539968580	S>N	B:591	(18.35, -6.92, 41.58)
1:182550491	rs534960363	R>C	B:592	(21.87, -10.84, 42.05)
1:182550481	rs147890567	T>M	B:595	(22.50, -4.65, 37.77)
1:182550482		T>A	B:595	(22.50, -4.65, 37.77)
1:182550478	COSM4025862	L>H	B:596	(23.92, -7.57, 34.92)
1:182550475	rs375872977	R>Q	B:597	(18.72, -5.90, 32.05)
1:182550476		R>W	B:597	(18.72, -5.90, 32.05)
1:182550463	rs142133260	N>S	B:601	(22.05, 0.25, 28.47)
1:182550455	rs369109378	D>N	B:604	(30.54, 3.24, 26.20)
1:182550451		I>T	B:605	(29.27, -1.73, 26.68)
1:182550448		K>R	B:606	(25.42, -0.43, 23.63)
1:182550445		T>I	B:607	(29.63, 1.03, 21.17)
1:182550442		R>Q	B:608	(32.84, -3.63, 20.58)
1:182550432	rs376567380	E>D	B:611	(40.93, 3.59, 25.15)
1:182550426		E>D	B:613	(35.84, 4.92, 32.56)
1:182550418	rs147610466	R>T	B:616	(39.75, 1.34, 32.61)
1:182550419		R>G	B:616	(39.75, 1.34, 32.61)
1:182550388		S>C	B:626	(39.24, -19.40, 35.73)
1:182550385	rs149964724	K>R	B:627	(36.62, -15.98, 35.84)
1:182550371		W>R	B:632	(30.09, -14.78, 26.29)
1:182550367		T>M	B:633	(30.08, -17.24, 23.20)
1:182550361		K>R	B:635	(29.88, -21.95, 27.97)
1:182545518	COSM1336954	E>K	B:638	(24.26, -23.82, 19.15)
1:182545511		V>G	B:640	(19.99, -18.44, 21.91)
1:182545508		M>K	B:641	(24.49, -16.91, 20.50)
1:182545484		E>G	B:649	(23.49, -10.85, 9.54)
1:182545479		R>G	B:651	(27.68, -2.86, 10.00)
1:182545476		G>R	B:652	(29.57, -8.47, 11.77)
1:182545466		Y>F	B:655	(27.18, -10.65, 20.82)
1:182545455	rs563976843	V>L	B:659	(32.92, -8.81, 30.16)
1:182545436	rs200188532	F>C	B:665	(23.71, -11.79, 25.31)
1:182545433		I>T	B:666	(22.60, -9.92, 29.78)
1:182545434	rs368181945	I>V	B:666	(22.60, -9.92, 29.78)
1:182545431	rs374614472	R>W	B:667	(20.16, -4.44, 26.83)
1:182545414		H>Q	B:672	(14.23, -9.60, 23.25)
1:182545412	rs150721457	I>T	B:673	(12.61, -12.19, 26.87)
1:182545413	rs200240346	I>V	B:673	(12.61, -12.19, 26.87)
1:182545391	rs199662278	K>R	B:680	(10.41, -19.33, 20.37)
1:182544712		M>L	B:681	(14.47, -17.16, 23.42)
1:182544702	rs373233085	K>R	B:684	(15.59, -22.98, 24.57)
1:182544687	rs138978618	S>F	B:689	(18.24, -14.43, 36.74)
1:182544676	rs377323259	Q>E	B:693	(22.96, -16.17, 38.67)
1:182544655		V>M	B:700	(27.40, -10.59, 40.06)
1:182544616		R>G	B:713	(28.41, 3.80, 42.83)

4OAV.B | RNASEL.

4OAV.B | RNASEL

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants