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2CUD.A | SLA.

2CUD.A | SLA

General Structure Information

PDB ID 2cud
HGNC Gene Label(s) SLA
Structure Name solution structure of the sh3 domain of the human src-like adopter protein (slap)
Resolution -1.0Å
Reference AUTH S.OHNISHI,T.KIGAWA,N.TOCHIO,M.SATO,N.NAMEKI,AUTH 2 S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 SRC-LIKE ADOPTER PROTEIN (SLAP)REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues 66
Number Of SNVs 16
Number Of Permutations 1981
Optimal Distance Threshold 6.0
K Statistic 0.075
p-value 0.89
COSMIC

Number Of Residues 66
Number Of SNVs 4
Number Of Permutations 45
Optimal Distance Threshold 13.0
K Statistic 0.167
p-value 0.705

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs 16
Number Of COSMIC SNVs 4
Optimal Distance Threshold 10.0
K Statistic -0.217
p-value 0.552

Mapped Variants

[+] ExAC Missense Variants

Position Variant AA Change PDB Chain Position Structure Coordinates
8:134072363 rs4486183 P>T A:8 (1.11, -12.37, -22.83)
8:134072352 N>K A:11 (-2.01, -10.31, -13.93)
8:134072347 rs267601780 E>G A:13 (-4.97, -15.11, -14.98)
8:134072348 E>K A:13 (-4.97, -15.11, -14.98)
8:134063157 L>P A:15 (-1.51, -18.13, -7.74)
8:134063154 rs373780212 D>G A:16 (-4.79, -14.34, -5.34)
8:134063149 rs148579032 D>N A:18 (-1.15, -10.41, -0.51)
8:134063140 A>S A:21 (-5.77, -1.37, 2.89)
8:134063137 V>M A:22 (-3.47, 3.10, 2.87)
8:134063100 P>L A:34 (0.61, 11.46, 1.19)
8:134063096 rs202161135 I>M A:35 (3.37, 7.66, -1.79)
8:134063091 rs201581025
COSM247341
COSM1096327
R>H A:37 (-5.07, 10.19, 0.78)
8:134063092 R>C A:37 (-5.07, 10.19, 0.78)
8:134063073 rs140863357 R>H A:43 (0.06, -6.49, -6.82)
8:134062192 rs554349415 R>Q A:61 (3.23, 7.62, -7.08)
8:134062178 rs147272641 P>S A:66 (4.95, 0.94, 7.47)
8:134062172 I>L A:68 (1.37, -0.57, 11.60)
8:134062169 rs536012943
COSM204382
C>S A:69 (0.83, 2.25, 7.66)

[+] COSMIC Missense Variants

Position Variant AA Change PDB Chain Position Structure Coordinates
8:134072357 COSM1645178 P>T A:10 (1.28, -9.11, -16.40)
8:134063091 COSM1096327 R>H A:37 (-5.07, 10.19, 0.78)
8:134063073 COSM1455002 R>H A:43 (0.06, -6.49, -6.82)
8:134063074 COSM3318370 R>C A:43 (0.06, -6.49, -6.82)
8:134062163 COSM1455000 A>S A:71 (-4.69, -3.29, 6.26)
Related Entries
2WTK|STRADA,CAB39,STK11
3F5N|SERPINI1
2WTK|STRADA,CAB39,STK11

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