General Structure Information
| PDB ID | 4bhw |
| HGNC Gene Label(s) | EP300 |
| Structure Name | structural basis for autoinhibition of the acetyltransferase activity of p300 |
| Resolution | 2.8Å |
| Reference | AUTH M.DELVECCHIO,J.GAUCHER,C.AGUILAR-GURRIERI,E.ORTEGA,D.PANNETITL STRUCTURE OF THE P300 CATALYTIC CORE AND IMPLICATIONS FORTITL 2 CHROMATIN TARGETING AND HAT REGULATIONREF NAT.STRUCT.MOL.BIOL. V. 20 1040 2013REFN ISSN 1545-9993PMID 23934153DOI 10.1038/NSMB.2642 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 563 |
| Number Of SNVs | 66 |
| Number Of Permutations | 51689 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.067 |
| p-value | 0.805 |
COSMIC
| Number Of Residues | 563 |
| Number Of SNVs | 16 |
| Number Of Permutations | 3358 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.575 |
| p-value | 0.001 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 15 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.176 |
| p-value | 0.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
