General Structure Information
| PDB ID | 3coa |
| HGNC Gene Label(s) | FOXO1 |
| Structure Name | crystal structure of foxo1 dbd bound to ire dna |
| Resolution | 2.2Å |
| Reference | AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 86 |
| Number Of SNVs | 6 |
| Number Of Permutations | 438 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.0 |
| p-value | 0.837 |
COSMIC
| Number Of Residues | 86 |
| Number Of SNVs | 3 |
| Number Of Permutations | 207 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.333 |
| p-value | 0.878 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 6 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.267 |
| p-value | 0.871 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
