General Structure Information
| PDB ID | 4gtu |
| HGNC Gene Label(s) | GSTM4 |
| Structure Name | ligand-free homodimeric human glutathione s-transferase m4-4 |
| Resolution | 3.3Å |
| Reference | AUTH Y.V.PATSKOVSKY,L.N.PATSKOVSKA,I.LISTOWSKYTITL AN ASPARAGINE-PHENYLALANINE SUBSTITUTION ACCOUNTS FORTITL 2 CATALYTIC DIFFERENCES BETWEEN HGSTM3-3 AND OTHER HUMAN CLASSTITL 3 MU GLUTATHIONE S-TRANSFERASES.REF BIOCHEMISTRY V. 38 16187 1999REFN ISSN 0006-2960PMID 10587441DOI 10.1021/BI991714T |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 217 |
| Number Of SNVs | 49 |
| Number Of Permutations | 16063 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.193 |
| p-value | 0.467 |
COSMIC
| Number Of Residues | 217 |
| Number Of SNVs | 3 |
| Number Of Permutations | 46 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.811 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 49 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.175 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
