General Structure Information
| PDB ID | 2ce8 |
| HGNC Gene Label(s) | TLE1 |
| Structure Name | an eh1 peptide bound to the groucho-tle wd40 domain. |
| Resolution | 2.03Å |
| Reference | AUTH B.H.JENNINGS,L.M.PICKLES,S.M.WAINWRIGHT,S.M.ROE,L.H.PEARL,AUTH 2 D.ISH-HOROWICZTITL MOLECULAR RECOGNITION OF TRANSCRIPTIONAL REPRESSOR MOTIFSTITL 2 BY THE WD DOMAIN OF THE GROUCHO/TLE COREPRESSOR.REF MOL.CELL V. 22 645 2006REFN ISSN 1097-2765PMID 16762837DOI 10.1016/J.MOLCEL.2006.04.024 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 328 |
| Number Of SNVs | 51 |
| Number Of Permutations | 6359 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.117 |
| p-value | 0.133 |
COSMIC
| Number Of Residues | 328 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1715 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.393 |
| p-value | 0.578 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.181 |
| p-value | 0.333 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
