General Structure Information
| PDB ID | 3tsz |
| HGNC Gene Label(s) | TJP1 |
| Structure Name | crystal structure of pdz3-sh3-guk core module from human zo-1 in complex with 12mer peptide from human jam-a cytoplasmic tail |
| Resolution | 2.5Å |
| Reference | AUTH J.NOMME,A.S.FANNING,M.CAFFREY,M.F.LYE,J.M.ANDERSON,A.LAVIETITL THE SRC HOMOLOGY 3 DOMAIN IS REQUIRED FOR JUNCTIONALTITL 2 ADHESION MOLECULE BINDING TO THE THIRD PDZ DOMAIN OF THETITL 3 SCAFFOLDING PROTEIN ZO-1.REF J.BIOL.CHEM. V. 286 43352 2011REFN ISSN 0021-9258PMID 22030391DOI 10.1074/JBC.M111.304089 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 341 |
| Number Of SNVs | 61 |
| Number Of Permutations | 16234 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.248 |
| p-value | 0.026 |
COSMIC
| Number Of Residues | 341 |
| Number Of SNVs | 4 |
| Number Of Permutations | 173 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.167 |
| p-value | 0.894 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.682 |
| p-value | 0.163 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
